Evidence map›Paper›PMID 37489135›Full record

ArticlebioRxiv : the preprint server for biology2023

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.

Lynn Bonetti, Veronika Horkova, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G Franchina, Leticia Soriano-Baguet, Melanie Grusdat, Sabine Spath, Eric Koncina and 17 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 6 countries.

Lynn BonettiExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Veronika HorkovaExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Joseph LongworthExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Luana GuerraExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Henry KurniawanExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Davide G FranchinaExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Leticia Soriano-BaguetExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Melanie GrusdatExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Sabine SpathInstitute of Experimental Immunology, Inflammation Research, University of Zurich, 8057 Zurich, Switzerland.
Eric KoncinaMolecular Disease Mechanisms Group, Department of Life Sciences and Medicine, University of Luxembourg, Belval, Luxembourg.
Anouk EwenExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Carole BinsfeldExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Charlène VerschuerenExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Jean-Jacques GérardyNational Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.
Takumi KobayashiExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Catherine DostertExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Sophie FarinelleExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Janika HärmExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Ying ChenDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Isaac S HarrisWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
Philipp A LangDepartment of Molecular Medicine II, Medical Faculty Heinrich Heine University Düsseldorf, Germany.
Vasilis VasiliouDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Ari WaismanInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Elisabeth LetellierMolecular Disease Mechanisms Group, Department of Life Sciences and Medicine, University of Luxembourg, Belval, Luxembourg.
Burkhard BecherInstitute of Experimental Immunology, Inflammation Research, University of Zurich, 8057 Zurich, Switzerland.
Michel MittelbronnNational Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.
Dirk BrennerExperimental and Molecular Immunology, Dept. of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
University of Luxembourg · LUUniversity of Zurich · CHHeinrich Heine University Düsseldorf · DEHusky (Luxembourg) · LUJohannes Gutenberg University Mainz · DEUniversity of Rochester Medical Center · USUniversity of Southern Denmark · DK

Funding

Mouse Models for Alcohol Metabolism and Tissue InjuryR24AA022057 · NIAAA · YALE UNIVERSITY · PI VASILIOU, VASILIS · 2013 to 2022
$4.5M
NIAAA NIH HHS R24 AA022057
6 · The paper itself

Abstract

Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, the mechanisms by which antioxidant defense in gut T cells contribute to intestinal homeostasis are currently unknown. Here we show, using T cell-specific ablation of the catalytic subunit of glutamate cysteine ligase (

Identifiers

PMID37489135
PMCPMC10363291
OpenAlexW4383498924

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.