Evidence map›Paper›PMID 37488892›Full record

ReviewNeural regeneration research2024

Advances in extracellular vesicle-based combination therapies for spinal cord injury.

Tingting Wang, Guohao Huang, Zhiheng Yi, Sihan Dai, Weiduan Zhuang, Shaowei Guo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural regeneration research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tingting WangDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Guohao HuangDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Zhiheng YiDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Sihan DaiDepartment of Biomedical Engineering, Shantou University, Shantou, Guangdong Province, China.
Weiduan ZhuangDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
Shaowei GuoDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury is a severe insult to the central nervous system that causes persisting neurological deficits. The currently available treatments involve surgical, medical, and rehabilitative strategies. However, none of these techniques can markedly reverse neurological deficits. Recently, extracellular vesicles from various cell sources have been applied to different models of spinal cord injury, thereby generating new cell-free therapies for the treatment of spinal cord injury. However, the use of extracellular vesicles alone is still associated with some notable shortcomings, such as their uncertainty in targeting damaged spinal cord tissues and inability to provide structural support to damaged axons. Therefore, this paper reviews the latest combined strategies for the use of extracellular vesicle-based technology for spinal cord injury, including the combination of extracellular vesicles with nanoparticles, exogenous drugs and/or biological scaffold materials, which facilitate the targeting ability of extracellular vesicles and the combinatorial effects with extracellular vesicles. We also highlight issues relating to the clinical transformation of these extracellular vesicle-based combination strategies for the treatment of spinal cord injury.

Indexed as

biomaterialscombination therapydrug deliveryexosomesextracellular vesiclesfunctional recoveryhydrogelsscaffoldsspinal cord injurytissue engineering

Identifiers

PMID37488892
PMCPMC10503620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.