Evidence map›Paper›PMID 37488870›Full record

ArticleNeural regeneration research2024

Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma (DBA/2J) mice.

Yin Yang, Zhaoxi Yang, Maoxia Lv, Ang Jia, Junjun Li, Baitao Liao, Jing'an Chen, Zhengzheng Wu, Yi Shi, Yang Xia and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. The role of RGC degeneration in the pathogenesis of glaucoma.International journal of biological sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yin YangDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Zhaoxi YangDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Maoxia LvDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Ang JiaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Junjun LiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Baitao LiaoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Jing'an ChenResearch Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, Sichuan Province; Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Zhengzheng WuDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Yi ShiHealth Management Center, Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China.
Yang XiaDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Dezhong YaoDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, Sichuan Province, China; Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; School of Electrical Engineering, Zhengzhou University, Zhengzhou, Henan Province, China.
Ke ChenDepartment of Ophthalmology, Sichuan Provincial People's Hospital, Medical School; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
University of Electronic Science and Technology of China · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide, and previous studies have shown that, in addition to affecting the eyes, it also causes abnormalities in the brain. However, it is not yet clear how the primary visual cortex (V1) is altered in glaucoma. This study used DBA/2J mice as a model for spontaneous secondary glaucoma. The aim of the study was to compare the electrophysiological and histomorphological characteristics of neurons in the V1 between 9-month-old DBA/2J mice and age-matched C57BL/6J mice. We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses, including single-unit spiking and gamma band oscillations. The morphology of layer II/III neurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections. Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined. Compared with the C57BL/6J group, V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation. Moreover, fewer neurons were observed in the V1 of DBA/2J mice compared with C57BL/6J mice. These findings suggest that DBA/2J mice have fewer neurons in the V1 compared with C57BL/6J mice, and that these neurons have impaired visual tuning. Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model. This study might offer some innovative perspectives regarding the treatment of glaucoma.

Indexed as

DBA/2Jdegenerationgamma band oscillationsglaucomaprimary visual cortex (V1)retinasingle-unit recordingtuning curve

Identifiers

PMID37488870
PMCPMC10479843
OpenAlexW4378218119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.