Evidence map›Paper›PMID 37488846›Full record

ReviewNeural regeneration research2024

Lactate metabolism in neurodegenerative diseases.

Chaoguang Yang, Rui-Yuan Pan, Fangxia Guan, Zengqiang Yuan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural regeneration research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 85 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chaoguang YangThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan Province, China.
Rui-Yuan PanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Fangxia GuanSchool of Life Sciences, Zhengzhou University, Zhengzhou, Henan Province, China.
Zengqiang YuanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Institute of Basic Medical Sciences of the Chinese Academy of Medical SciencesZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system. Moreover, protein lactylation highlights the novel role of lactate in regulating transcription, cellular functions, and disease development. This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases, thus providing optimal perspectives for future research.

Indexed as

Alzheimer’s diseaseAstrocyte-Neuron Lactate Shuttlebraincentral nervous systemglucose metabolismglycolysisneuroinflammationParkinson’s diseaseprotein lactylationsignaling molecule

Identifiers

PMID37488846
PMCPMC10479854
OpenAlexW4365795810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.