Evidence map›Paper›PMID 37488842›Full record

ReviewNeural regeneration research2024

Metabolic and proteostatic differences in quiescent and active neural stem cells.

Jiacheng Yu, Gang Chen, Hua Zhu, Yi Zhong, Zhenxing Yang, Zhihong Jian, Xiaoxing Xiong

Open access · goldAbstract readReview
In one paragraph

Review in Neural regeneration research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiacheng YuDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Gang ChenDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Hua ZhuDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Yi ZhongDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Zhenxing YangDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Zhihong JianDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Xiaoxing XiongDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Wuhan University · CNRenmin Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult neural stem cells are neurogenesis progenitor cells that play an important role in neurogenesis. Therefore, neural regeneration may be a promising target for treatment of many neurological illnesses. The regenerative capacity of adult neural stem cells can be characterized by two states: quiescent and active. Quiescent adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell pool. Active adult neural stem cells are characterized by rapid proliferation and differentiation into neurons which allow for integration into neural circuits. This review focuses on differences between quiescent and active adult neural stem cells in nutrition metabolism and protein homeostasis. Furthermore, we discuss the physiological significance and underlying advantages of these differences. Due to the limited number of adult neural stem cells studies, we referred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms.

Indexed as

adult neurogenesiscell metabolic pathwaycellular proliferationneural stem cell nichesneural stem cellsneuronal differentiationnutrient sensing pathwayproteostasis

Identifiers

PMID37488842
PMCPMC10479840
OpenAlexW4379052461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.