Evidence map›Paper›PMID 37488797›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Protective effects of total saponins from

B Zhou, C Zhang, H Deng, S Chen, Y Chang, Y Yang, G Fu, D Yuan, H Zhao

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

B ZhouThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
C ZhangThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
H DengThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
S ChenThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Y ChangThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Y YangThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
G FuThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
D YuanThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
H ZhaoThird-grade Pharmacological Laboratory on Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
China Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the protective effects of total saponins from

methodsForty male C57BL/6J mice were randomized into normal diet group, high-fat diet group, and low-dose (25 mg/kg) and high-dose (75 mg/kg) TSPJ treatment groups (

resultsTreatment with TSPJ significantly improved high-fat diet-induced testicular dysfunction by reducing body weight (

conclusionTSPJ alleviates high-fat diet-induced damages of testicular Sertoli cell junctions and spermatogenesis possibly by activating the AKT/mTOR signaling pathway and inhibiting autophagy of testicular Sertoli cells.

Indexed as

Sertoli CellsTestisAnimalsbeta CateninCadherinsDiet, High-FatIntercellular JunctionsMaleMiceMice, Inbred C57BLOccludinProto-Oncogene Proteins c-aktSeedsbeta CateninCadherinsOccludinProto-Oncogene Proteins c-aktautophagyhigh-fat dietsertoli cellstestistotal saponins, Panax japonicus

Identifiers

PMID37488797
PMCPMC10366514
OpenAlexW4385230814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.