Evidence map›Paper›PMID 37488607›Full record

ReviewHuman genomics2023

COVID-19 annual update: a narrative review.

Michela Biancolella, Vito Luigi Colona, Lucio Luzzatto, Jessica Lee Watt, Giorgio Mattiuz, Silvestro G Conticello, Naftali Kaminski, Ruty Mehrian-Shai, Albert I Ko, Gregg S Gonsalves and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Human genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 6 countries.

Michela Biancolella *Department of Biology, Tor Vergata University of Rome, 00133, Rome, Italy.
Vito Luigi Colona *Department of Biomedicine and Prevention, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy.
Lucio Luzzatto *Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Jessica Lee WattCollege of Public Health, Medical and Veterinary Sciences, James Cook University, Smithfield, QLD, 4878, Australia.
Giorgio MattiuzUniversity of Florence, 50121, Florence, Italy.
Silvestro G ConticelloCore Research Laboratory, Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy.
Naftali KaminskiPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Ruty Mehrian-ShaiPediatric Hemato-Oncology, Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 2 Sheba Road, 52621, Ramat Gan, Israel.
Albert I KoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, USA.
Gregg S GonsalvesDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Vasilis VasiliouDepartment of Environmental Health Sciences, School of Public Health, Yale University, New Haven, USA.
Giuseppe Novelli *Department of Biomedicine and Prevention, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy. novelli@med.uniroma2.it.
Juergen K V Reichardt *Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD, 4878, Australia.
Yale University · USUniversity of Florence · ITUniversity of Rome Tor Vergata · ITAustralian Institute of Tropical Health and Medicine · AUFundação Oswaldo Cruz · BRIstituto Neurologico Mediterraneo · ITIstituto per lo Studio e la Prevenzione Oncologica · ITJames Cook University · AUSheba Medical Center · IL

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Three and a half years after the pandemic outbreak, now that WHO has formally declared that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on recent developments in genetic and genomic research on COVID-19, and we give an outlook on state-of-the-art therapeutical approaches, as the pandemic is gradually transitioning to an endemic situation. The sequencing and characterization of rare alleles in different populations has made it possible to identify numerous genes that affect either susceptibility to COVID-19 or the severity of the disease. These findings provide a beginning to new avenues and pan-ethnic therapeutic approaches, as well as to potential genetic screening protocols. The causative virus, SARS-CoV-2, is still in the spotlight, but novel threatening virus could appear anywhere at any time. Therefore, continued vigilance and further research is warranted. We also note emphatically that to prevent future pandemics and other world-wide health crises, it is imperative to capitalize on what we have learnt from COVID-19: specifically, regarding its origins, the world's response, and insufficient preparedness. This requires unprecedented international collaboration and timely data sharing for the coordination of effective response and the rapid implementation of containment measures.

Indexed as

COVID-19Evolution, MolecularGenome-Wide Association StudyGenomicsHumansSARS-CoV-2CoronavirusCOVID-19PandemicPublic healthSARS-CoV-2Susceptibility genesTherapyVaccinesVariants

Identifiers

PMID37488607
PMCPMC10367267
OpenAlexW4385198668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.