ReviewNature reviews. Rheumatology2023
Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.
Review in Nature reviews. Rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- At least 150 min per week of Tai chi practice improves sleep quality in the older people: evidence from a meta-analysis.European geriatric medicine · 2025Pooled it
- Association Between Glucocorticoid Exposure and Objective Sleep Architecture in Rheumatoid Arthritis: An Exploratory Pilot EEG Study.Journal of clinical medicine · 2026Article
- Bidirectional associations between daily sleep and pain severity in adults with rheumatoid arthritis: A daily diary and actigraphy study.The journal of pain · 2026Article
- Examining the Role of Wearables in Inflammatory Arthritis Care: A Narrative Literature Review.The Journal of rheumatology · 2026Review
- Prevalence and competing risk of psychiatric comorbidities in chronic low back pain by age group.Pain reports · 2026Article
- Article
- Association Between Depressive Symptoms and Pain Intensity in Patients With Arthritis.Brain and behavior · 2026Article
- Prevalence of depressive and anxiety symptoms among patients consulting a rare disease outpatient clinic for rare and undiagnosed diseases in China.Orphanet journal of rare diseases · 2026Article
- Psychological consequences of insufficient sleep in medical students.Discover mental health · 2026Article
- Baseline pain, fatigue, and sleep quality predict 12-week pain improvement in inflammatory arthritis: retrospective real-world analysis of a digital health application cohort.Rheumatology international · 2026Article
- Sleep quality, duration, and multi-trajectories as predictors of rheumatoid arthritis: evidence from the english longitudinal study of ageing.Arthritis research & therapy · 2026Article
- Age of Onset in Insomnia: A Latent Profile Analysis.Journal of sleep research · 2026Article
- Causal Effects of Lifestyle and Dietary Factors on Rheumatoid Arthritis: An Integrated Analysis Combining Mendelian Randomization, Machine Learning, and Evaluation of Burden Dynamics and Health Inequality.Food science & nutrition · 2026Article
- A machine learning integrated multi-omics framework for risk prediction and target discovery in insomnia aggravated sepsis induced acute lung injury.Frontiers in immunology · 2026Article
- Inflammatory Cytokine-Mediated Interactions Between Pain and Insomnia: Mechanisms and Therapeutic Implications.Journal of pain research · 2026Review
- Suicidal ideation and interrelated psychiatric disturbances in rheumatoid arthritis: Evidence from a Vietnamese cohort.PloS one · 2026Article
- The mediating role of sleep quality in the association between inflammatory disease activity and health-related quality of life in rheumatoid arthritis.Frontiers in medicine · 2026Article
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Association Between Sleep Disturbance and Subsequent Pain Interference in Patients With Early Rheumatoid Arthritis.Arthritis care & research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Sleep has a homeostatic role in the regulation of the immune system and serves to constrain activation of inflammatory signalling and expression of cellular inflammation. In patients with rheumatoid arthritis (RA), a misaligned inflammatory profile induces a dysregulation of sleep-wake activity, which leads to excessive inflammation and the induction of increased sensitivity to pain. Given that multiple biological mechanisms contribute to sleep disturbances (such as insomnia), and that the central nervous system communicates with the innate immune system via neuroendocrine and neural effector pathways, potential exists to develop prevention opportunities to mitigate the risk of insomnia in RA. Furthermore, understanding these risk mechanisms might inform additional insomnia treatment strategies directed towards steering and reducing the magnitude of the inflammatory response, which together could influence outcomes of pain and disease activity in RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.