ArticleNature communications2023
In situ assembly of bioresorbable organic bioelectronics in the brain.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Direct arylation polymerization of electron-rich arenes with polar-group tolerance enabled by ligand-coordination tuning.Chemical science · 2026Article
- Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Electropolymerization of Organic Mixed Ionic-Electronic Conductors: Fundamentals and Applications in Bioelectronics.Chemical reviews · 2026Review
- Acoustic printing of conductive polymers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Injectable bioresorbable conductive hydrogels for multimodal brain tumor electroimmunotherapy.Nature communications · 2025Article
- From Molecules to Bioaggregates: Unraveling the Photoexcitation Dynamics of Intracellularly Self-Assembled Thiophene-Based Fibers.Small science · 2025Article
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Lithography-Free Water Stable Conductive Polymer Nanowires.Nano letters · 2025Article
- Bioresorbable electrodes in implantable electronic healthcare devices.Frontiers in bioengineering and biotechnology · 2025Review
- Enzymatically Polymerized Organic Conductors on Native Lipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- In Vivo Photopolymerization: Achieving Detailed Conducting Patterns for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Engineering Conductive Hydrogels with Tissue-like Properties: A 3D Bioprinting and Enzymatic Polymerization Approach.Small science · 2024Article
- In situ assembly of an injectable cardiac stimulator.Nature communications · 2024Article
- Blood-Catalyzed Polymerization Creates Conductive Polymer in Live Zebrafish.Research square · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria and integrate seamlessly into dynamic biological systems in ways difficult for classical rigid solid-state electronics. Here we place bioresorbable electrodes with a brain-matched shear modulus-made from water-dispersed nanoparticles in the brain-in the targeted area using a capillary thinner than a human hair. Thereafter, we show that an optional auxiliary module grows dendrites from the installed conductive structure to seamlessly embed neurons and modify the electrode's volume properties. We demonstrate that these soft electrodes set off a controlled cellular response in the brain when relaying external stimuli and that the biocompatible materials show no tissue damage after bioresorption. These findings encourage further investigation of temporary organic bioelectronics for nonchronic treatments assembled in vivo.
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Registered trials
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