Evidence map›Paper›PMID 37488009›Full record

ArticleExperimental eye research2023

FoxC1 activates limbal epithelial stem cells following corneal epithelial debridement.

Wending Yang, Sun Kyong Lee, Ordan J Lehmann, Zhijian Wu, Suja Hiriyanna, Anand Swaroop, Robert M Lavker, Han Peng, Tsutomu Kume

Open access · greenAbstract read
In one paragraph

Article in Experimental eye research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. IFITM1/OVOL1 Axis Is a Novel Regulator of the Expansion of the Limbal Epithelial Stem/Early Transient Amplifying Cell Population.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Wending YangDepartments of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Sun Kyong LeeDepartments of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Ordan J LehmannDepartment of Ophthalmology and Medical Genetics, University of Alberta, Edmonton, Alberta, T6G, 2H7, Canada.
Zhijian WuNeurobiology Neurodegeneration& Repair Laboratory (N-NRL), National Eye Institute, NIH, Bethesda, MD, 20892, USA.
Suja HiriyannaNeurobiology Neurodegeneration& Repair Laboratory (N-NRL), National Eye Institute, NIH, Bethesda, MD, 20892, USA.
Anand SwaroopNeurobiology Neurodegeneration& Repair Laboratory (N-NRL), National Eye Institute, NIH, Bethesda, MD, 20892, USA.
Robert M LavkerDepartments of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: r-lavker@northwestern.edu.
Han PengDepartments of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: han-peng@northwestern.edu.
Tsutomu KumeDepartments of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: t-kume@northwestern.edu.
Northwestern University · USNational Eye Institute · USUniversity of Alberta · CA

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Regulation of retinal developmentZIAEY000450 · NEI · NATIONAL EYE INSTITUTE · PI SWAROOP, ANAND · 2009 to 2025
$71.0M
Northwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amy S Paller · 2019 to 2026
$6.6M
The Role of MicroRNAs in Corneal Epithelial HomeostasisR01EY019463 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LAVKER, ROBERT M · 2010 to 2022
$5.0M
The Roles of Autophagy in Limbal/Corneal Epithelia.R01EY028560 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Han Peng · 2018 to 2026
$3.9M
Single-cell RNA sequencing reveals novel regulatory pathways in maintaining limbal epithelial stem cell homeostasisR01EY032922 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PENG, HAN · 2021 to 2025
$2.0M
NCI NIH HHS P30 CA060553NEI NIH HHS R01 EY019463NEI NIH HHS R01 EY028560NEI NIH HHS R01 EY032922NIAMS NIH HHS P30 AR075049
6 · The paper itself

Abstract

Limbal epithelial stem cells are not only critical for corneal epithelial homeostasis but also have the capacity to change from a relatively quiescent mitotic phenotype to a rapidly proliferating cell in response to population depletion following corneal epithelial wounding. Pax6

Indexed as

Corneal DiseasesEpithelium, CornealLimbus CorneaeAnimalsCorneaDebridementEpithelial CellsForkhead Transcription FactorsHumansMiceStem CellsForkhead Transcription FactorsFOXC1 protein, humanCorneal woundingFoxC1Limbal stem cell deficiencyPax6Proliferation

Identifiers

PMID37488009
PMCPMC10530263
OpenAlexW4385142868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.