Evidence map›Paper›PMID 37488007›Full record

ArticleExperimental eye research2023

Improved magnetic delivery of cells to the trabecular meshwork in mice.

M Reza Bahrani Fard, Jessica Chan, Gabriela Sanchez Rodriguez, Marybeth Yonk, Shreya R Kuturu, A Thomas Read, Stanislav Y Emelianov, Markus H Kuehn, C Ross Ethier

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Modeling complex age-related eye disease.Progress in retinal and eye research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

M Reza Bahrani FardWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Jessica ChanSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Gabriela Sanchez RodriguezSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Marybeth YonkCollege of Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Shreya R KuturuDepartment of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
A Thomas ReadWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Stanislav Y EmelianovSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
Markus H KuehnDepartments of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA; Veterans Administration Center for the Prevention and Treatment of Visual Loss, Iowa City VA Healthcare System, Iowa City, IA, USA.
C Ross EthierWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA. Electronic address: ross.ethier@bme.gatech.edu.
Georgia Institute of Technology · USUniversity of Iowa · US

Funding

Magnetic Steering and Longitudinal Visualization of Stem Cells for Trabecular Meshwork Therapy in GlaucomaR01EY030071 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI EMELIANOV, STANISLAV Y, ETHIER, C ROSS · 2019 to 2022
$2.3M
NEI NIH HHS R01 EY030071RRD VA I01 RX001163
6 · The paper itself

Abstract

Glaucoma is the leading cause of irreversible blindness worldwide and its most prevalent subtype is primary open angle glaucoma (POAG). One pathological change in POAG is loss of cells in the trabecular meshwork (TM), which is thought to contribute to ocular hypertension and has thus motivated development of cell-based therapies to refunctionalize the TM. TM cell therapy has shown promise in intraocular pressure (IOP) control, but existing cell delivery techniques suffer from poor delivery efficiency. We employed a novel magnetic delivery technique to reduce the unwanted side effects of off-target cell delivery. Mesenchymal stem cells (MSCs) were labeled with superparamagnetic iron oxide nanoparticles (SPIONs) and after intracameral injection were magnetically steered towards the TM using a focused magnetic apparatus ("point magnet"). This technique delivered the cells significantly closer to the TM at higher quantities and with more circumferential uniformity compared to either unlabeled cells or those delivered using a "ring magnet" technique. We conclude that our point magnet cell delivery technique can improve the efficiency of TM cell therapy and in doing so, potentially increase the therapeutic benefits and lower the risk of complications such as tumorigenicity and immunogenicity.

Indexed as

GlaucomaGlaucoma, Open-AngleAnimalsIntraocular PressureMagnetic PhenomenaMiceTrabecular MeshworkCell delivery efficiencyCell therapyIOPMagnetic cell deliveryPrimary open angle glaucomaTrabecular meshwork

Identifiers

PMID37488007
PMCPMC10530071
OpenAlexW4385076786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.