Evidence map›Paper›PMID 37488003›Full record

ArticleThe Annals of thoracic surgery2024

Furosemide Responsiveness Predicts Acute Kidney Injury Progression After Cardiac Surgery.

Ying Su, Yi-Jie Zhang, Guo-Wei Tu, Jun-Yi Hou, Guo-Guang Ma, Guang-Wei Hao, Rong-Hui Xu, Zhe Luo

Open access · bronzeAbstract read
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In one paragraph

Article in The Annals of thoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ying SuCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Yi-Jie ZhangCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Guo-Wei TuCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Jun-Yi HouCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Guo-Guang MaCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Guang-Wei HaoCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Rong-Hui XuDepartment of Mathematics, Halicioglu Data Science Institute, University of California, San Diego, La Jolla, California.
Zhe LuoCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Lung Inflammation and Injury, Shanghai, China; Department of Critical Care Medicine, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China. Electronic address: luo.zhe@zs-hospital.sh.cn.
Fudan University · CNShanghai University · CNUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs patients with acute kidney injury (AKI) progress to a higher stage, the risk for poor outcomes dramatically rises. Early identification of patients at high risk for AKI progression remains a major challenge. This study aimed to evaluate the value of furosemide responsiveness (FR) for predicting AKI progression in patients with initial mild and moderate AKI after cardiac surgery.

methodsWe performed 2 separate exploratory analyses. The Zhongshan cohort was a single-center, prospective, observational cohort, whereas the Beth Israel Deaconess Medical Center cohort was a single-center, retrospective cohort. We calculated 2 FR parameters for each patient, namely the FR index and modified FR index, defined as 2-hour urine output divided by furosemide dose (FR index, mL/mg/2 h) and by furosemide dose and body weight (modified FR index, mL/[mg·kg]/2 h), respectively. The primary outcome was AKI progression within 7 days.

resultsAKI progression occurred in 80 (16.0%) and 359 (11.3%) patients in the Zhongshan and Beth Israel Deaconess Medical Center cohorts, respectively. All FR parameters (considered continuously or in quartiles) were inversely associated with risk of AKI progression in both cohorts (all adjusted P < .01). The addition of FR parameters significantly improved prediction for AKI progression based on baseline clinical models involving C-index, net reclassification improvement, and integrated discrimination improvement index in both cohorts (all P < .01).

conclusionsFR parameters were inversely associated with risk of AKI progression in patients with mild and moderate AKI after cardiac surgery. The addition of FR parameters significantly improved prediction for AKI progression based on baseline clinical models.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresFurosemideHumansPostoperative ComplicationsProspective StudiesRetrospective StudiesFurosemide

Identifiers

PMID37488003
OpenAlexW4385163694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.