Evidence map›Paper›PMID 37487846›Full record

ArticleUrologic oncology2023

Evaluation of sarcopenia in patients receiving intravesical Bacillus Calmette-Guérin for non-muscle invasive bladder cancer.

Syed M Alam, Matthew Larson, Pugazhendhi Srinivasan, Nick Genz, Ryan Fleer, Mihaela Sardiu, Jeffrey Thompson, Eugene Lee, Jill Hamilton-Reeves, Elizabeth Wulff-Burchfield

Abstract read
In one paragraph

Article in Urologic oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Syed M AlamDepartment of Urology, University of Kansas Health System, Kansas City, KS.
Matthew LarsonDepartment of Urology, University of Kansas Health System, Kansas City, KS.
Pugazhendhi SrinivasanDepartment of Dietetics and Nutrition, University of Kansas, Kansas City, KS.
Nick GenzDepartment of Urology, University of Kansas Health System, Kansas City, KS.
Ryan FleerDepartment of Pharmacy Practice, University of Kansas Health System, Kansas City, KS.
Mihaela SardiuDepartment of Biostatistics, University of Kansas, Kansas City, KS.
Jeffrey ThompsonDepartment of Biostatistics, University of Kansas, Kansas City, KS.
Eugene LeeDepartment of Urology, University of Kansas Health System, Kansas City, KS.
Jill Hamilton-ReevesDepartment of Urology, University of Kansas Health System, Kansas City, KS; Department of Dietetics and Nutrition, University of Kansas, Kansas City, KS; Department of Medicine, Division of Medical Oncology, University of Kansas, Kansas City, KS.
Elizabeth Wulff-BurchfieldDepartment of Medicine, Division of Medical Oncology, University of Kansas, Kansas City, KS. Electronic address: ewulffburchfield@kumc.edu.
University of Kansas · USUniversity of Kansas Medical Center · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Effect of Immune-Enhancing Nutrition on Radical Cystectomy Outcomes- MERIT extensionR37CA218118 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HAMILTON-REEVES, JILL REEVES · 2018 to 2024
$4.0M
NCI NIH HHS P30 CA168524NCI NIH HHS R37 CA218118
6 · The paper itself

Abstract

backgroundSarcopenia is associated with adverse outcomes for patients with muscle invasive bladder cancer (MIBC), but less is known about its impact in the setting of non-muscle invasive bladder cancer (NMIBC). Sarcopenia, skeletal muscle density, and adipose tissue area have been studied as markers of malnutrition and can be determined radiographically. The purpose of this study is to characterize the prevalence of sarcopenia in patients with NMIBC receiving intravesical Bacillus Calmette-Guérin (BCG).

methodsFollowing institutional review board approval, patients with NMIBC having received intravesical BCG were identified using institutional pharmacy records. Patients having undergone computed tomography (CT) of the abdomen and pelvis within 90 days of treatment were included in the analysis. Using sliceOmatic 5.0 software, skeletal muscle area (cm

resultsA total of 308 patients having received BCG between 2015 and 2020 were identified, of which 90 met criteria for analysis. Nearly all (94%) patients completed at least 5 out of 6 BCG induction instillations. Median body mass index (kg/m

conclusionsSarcopenia and frailty are highly prevalent amongst patients with NMIBC. A diagnosis of NMIBC represents a window of opportunity to identify and intervene on modifiable risk factors such as sarcopenia and frailty, which are associated with adverse outcomes in more advanced disease states.

Indexed as

FrailtyNon-Muscle Invasive Bladder NeoplasmsSarcopeniaUrinary Bladder NeoplasmsAdjuvants, ImmunologicAdministration, IntravesicalBCG VaccineFemaleHumansMaleNeoplasm InvasivenessNeoplasm Recurrence, LocalAdjuvants, ImmunologicBCG VaccineBody compositionLocalMalnutritionNeoplasm recurrenceSarcopeniaUrinary bladder neoplasms

Identifiers

PMID37487846
PMCPMC13036759
OpenAlexW4385073663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.