Evidence map›Paper›PMID 37487741›Full record

ArticleeNeuro2023

Estradiol Receptors Inhibit Long-Term Potentiation in the Dorsomedial Striatum.

Valerie J Lewitus, Kim T Blackwell

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Valerie J LewitusInterdisciplinary Neuroscience PhD Program.ORCID 0000-0002-6456-6156
Kim T BlackwellInterdisciplinary Neuroscience PhD Program klblackwell@uiowa.edu.
George Mason University · US

Funding

CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger PathwaysR01AA016022 · NIAAA · GEORGE MASON UNIVERSITY · PI BLACKWELL, KIM L, LOVINGER, DAVID · 2005 to 2017
$2.6M
Estradiol signaling pathways mediating sex differences in striatal synaptic plasticityR01DA056113 · NIDA · UNIVERSITY OF IOWA · PI Kim L Blackwell · 2023 to 2026
$2.4M
CRCNS: US-French Collaboration: Dopamine modulation of calcium in STDPR01DA038890 · NIDA · GEORGE MASON UNIVERSITY · PI BLACKWELL, KIM L · 2014 to 2017
$637k
NIAAA NIH HHS R01 AA016022NIDA NIH HHS R01 DA038890NIDA NIH HHS R01 DA056113
6 · The paper itself

Abstract

Estradiol, a female sex hormone and the predominant form of estrogen, has diverse effects throughout the brain including in learning and memory. Estradiol modulates several types of learning that depend on the dorsomedial striatum (DMS), a subregion of the basal ganglia involved in goal-directed learning, cued action-selection, and motor skills. A cellular basis of learning is synaptic plasticity, and the presence of extranuclear estradiol receptors ERα, ERβ, and G-protein-coupled estrogen receptor (GPER) throughout the DMS suggests that estradiol may influence rapid cellular actions including those involved in plasticity. To test whether estradiol affects synaptic plasticity in the DMS, corticostriatal long-term potentiation (LTP) was induced using theta-burst stimulation (TBS) in

Indexed as

Long-Term PotentiationReceptors, EstradiolAnimalsEstradiolEstrogen Receptor alphaEstrogensFemaleMaleMiceMice, Inbred C57BLReceptors, EstrogenEstradiolEstrogen Receptor alphaEstrogensReceptors, EstradiolReceptors, Estrogendorsal striatumestrogenestrous cyclelong-term potentiationsex differencessynaptic plasticity

Identifiers

PMID37487741
PMCPMC10405883
OpenAlexW4385210011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.