Evidence map›Paper›PMID 37487739›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Activation of Basal Forebrain Astrocytes Induces Wakefulness without Compensatory Changes in Sleep Drive.

Ashley M Ingiosi, Christopher R Hayworth, Marcos G Frank

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Astrocytes at the heart of sleep: from genes to network dynamics.Cellular and molecular life sciences : CMLS · 2025
    Review
  4. Sleep and immune health: How dogs, goats and 'factor S' shaped a field.Neurobiology of sleep and circadian rhythms · 2025
    Article
  5. [Activation of astrocytes in the dorsomedial hypothalamus accelerates sevoflurane anesthesia emergence in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ashley M IngiosiDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington 99202.
Christopher R HayworthDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington 99202.
Marcos G FrankDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington 99202 marcos.frank@wsu.edu.
Washington State University Spokane · US

Funding

Astroglial mechanisms in sleep homeostasisR01NS114780 · NINDS · WASHINGTON STATE UNIVERSITY · PI FRANK, MARCOS G · 2020 to 2024
$3.4M
Non-neuronal regulators of sleepR01MH099544 · NIMH · WASHINGTON STATE UNIVERSITY · PI ABEL, EDWIN TED G., FRANK, MARCOS G · 2013 to 2017
$2.0M
Dissecting the role of neuronal-astroglial interactions in sleep homeostasisK99NS119293 · NINDS · WASHINGTON STATE UNIVERSITY · PI INGIOSI, ASHLEY MIRANDA · 2021 to 2022
$245k
Contributions of Astroglial Calcium Activity to Sleep HomeostasisF32NS100335 · NINDS · WASHINGTON STATE UNIVERSITY · PI INGIOSI, ASHLEY MIRANDA · 2017 to 2019
$179k
NIMH NIH HHS R01 MH099544NINDS NIH HHS F32 NS100335NINDS NIH HHS K99 NS119293NINDS NIH HHS R01 NS114780
6 · The paper itself

Abstract

Mammalian sleep is regulated by a homeostatic process that increases sleep drive and intensity as a function of prior wake time. Sleep homeostasis has traditionally been thought to be a product of neurons, but recent findings demonstrate that this process is also modulated by glial astrocytes. The precise role of astrocytes in the accumulation and discharge of sleep drive is unknown. We investigated this question by selectively activating basal forebrain (BF) astrocytes using designer receptors exclusively activated by designer drugs (DREADDs) in male and female mice. DREADD activation of the G

Indexed as

Basal ForebrainWakefulnessAnimalsAstrocytesFemaleMaleMammalsMiceNeuronsSleepastrocytebasal forebrainchemogeneticsDREADDhomeostasissleep

Identifiers

PMID37487739
PMCPMC10423050
OpenAlexW4385191654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.