Evidence map›Paper›PMID 37487656›Full record

ArticleOpen heart2023

Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy.

Simon Winther, Laust Dupont Rasmussen, Jelmer Westra, Salma Raghad Karim Abdulzahra, Jonathan Nørtoft Dahl, Lars Christian Gormsen, Evald Høj Christiansen, Gitte Stokvad Brix, Jesper Mortensen, June Anita Ejlersen and 9 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04707859 (Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease 3), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04707859 unknown statusnot on this map

Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease 3

TypeobservationalSponsorUniversity of AarhusRan2021 to 2023Enrolled1,000ConditionsAngina Pectoris, Atherosclerosis, Coronary Artery Disease, Myocardial IschemiaArmsHead to head comparison: Rubidium vs 15O-water PET
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Coronary microvascular disease in patients referred to coronary angiography following coronary computed tomography angiography.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Observational
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Simon WintherDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark.ORCID 0000-0001-8872-3681
Laust Dupont RasmussenDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark.ORCID 0000-0002-2790-2608
Jelmer WestraDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Salma Raghad Karim AbdulzahraDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Jonathan Nørtoft DahlDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark.
Lars Christian GormsenDepartment of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark.
Evald Høj ChristiansenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Gitte Stokvad BrixDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark.
Jesper MortensenDepartment of Nuclear Medicine, Gødstrup Hospital, Herning, Denmark.
June Anita EjlersenDepartment of Nuclear Medicine, Regional Hospital Central Jutland, Viborg, Denmark.
Hanne Maare SøndergaardDepartment of Cardiology, Regional Hospital Central Jutland, Viborg, Denmark.
Nicolaj Christopher Lyng HanssonDepartment of Cardiology, Regional Hospital Central Jutland, Viborg, Denmark.
Niels Ramsing HolmDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-2316-3107
Lars Lyhne KnudsenDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark.
Ashkan EftekhariDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0003-2871-8279
Peter L MøllerDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Palle Duun RohdeDepartment of Health, Science and Technology, Aalborg University, Aalborg, Denmark.
Mette NyegaardHealth Science and Technology, Aalborg Universitet, Gistrup, Denmark.ORCID 0000-0003-4973-8543
Morten BöttcherDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark morboett@rm.dk.
Aarhus University Hospital · DKRegional Hospital Central Jutland · DKAalborg University · DKAalborg University Hospital · DKAarhus University · DKRegionshospitalet Herning · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCurrent guideline recommend functional imaging for myocardial ischaemia if coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain functional significance. However, diagnostic accuracy of selective myocardial perfusion imaging after coronary CTA is currently unclear. The Danish study of Non-Invasive testing in Coronary Artery Disease 3 trial is designed to evaluate head to head the diagnostic accuracy of myocardial perfusion imaging with positron emission tomography (PET) using the tracers METHODS AND ANALYSIS: This prospective, multicentre, cross-sectional study will include approximately 1000 symptomatic patients without previous CAD. Patients are included after referral to coronary CTA. All patients undergo a structured interview and blood is sampled for genetic and proteomic analysis and a coronary CTA. Patients with possible obstructive CAD at coronary CTA are examined with both ETHICS AND DISSEMINATION: Ethical approval was obtained from Danish regional committee on health research ethics. Written informed consent will be provided by all study participants. Results of this study will be disseminated via articles in international peer-reviewed journal. TRIAL REGISTRATION NUMBER: NCT04707859.

Indexed as

Coronary Artery DiseaseFractional Flow Reserve, MyocardialCross-Sectional StudiesDenmarkHumansMulticenter Studies as TopicProspective StudiesProteomicsWaterWatercoronary artery diseasediagnostic imagingpositron-emission tomography

Identifiers

PMID37487656
PMCPMC10373750
OpenAlexW4385220619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.