ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2023
Progression of stroke risk in patients aged <65 years diagnosed with atrial fibrillation: a cohort study in general practice.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAs a result of new technologies, atrial fibrillation (AF) is more likely to be diagnosed in people aged <65 years.
aimTo investigate the risk of someone diagnosed with AF aged <65 years developing an indication for anticoagulation before they reach 65 years. DESIGN AND
settingPopulation-based cohort study of patients from English practices using the Clinical Practice Research Datalink, a primary care database of electronic medical records.
methodThe study included patients aged <65 years newly diagnosed with AF. The CHA
resultsAmong 18 178 patients aged <65 years diagnosed with AF, 9188 (50.5%) were eligible for anticoagulation at the time of diagnosis. Among the 8990 patients not eligible for anticoagulation, 1688 (18.8%) developed a risk factor during follow-up before reaching 65 years of age or leaving the cohort for other reasons, at a rate of 6.1 per 100 patient-years. Hypertension and heart failure were the most common risk factors to occur, with rates of 2.65 (95% CI = 2.47 to 2.84) and 1.58 (95% CI = 1.45 to 1.72) per 100 patient-years, respectively. The rate of new diabetes was 0.95 (95% CI = 0.85 to 1.06) per 100 patient-years.
conclusionPeople aged <65 years with AF are at higher risk of developing hypertension, heart failure, and diabetes than the general population, so may warrant regular review to identify new occurrence of such risk factors.
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