Evidence map›Paper›PMID 37487563›Full record

ArticleThe American journal of tropical medicine and hygiene2023

Case Report: A Case of Bone Marrow Necrosis and Hyperinflammation in a 10-Year-Old Boy after Plasmodium falciparum Infection.

Caitlyn Hui, Alessandra Bosch, Oscar Mwizerwa, Jeanine McColl, Antoine Corbeil, Caroline Malcolmson, Deborah M Levy, Zia Bismilla, Shaun K Morris

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Caitlyn HuiDivision of Pediatric Infectious Diseases, The Hospital for Sick Children, Toronto, Canada.
Alessandra BoschDepartment of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Oscar MwizerwaDepartment of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Jeanine McCollDepartment of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Antoine CorbeilMicrobiology and Laboratory Science, Public Health Ontario, Toronto, Canada.
Caroline MalcolmsonDepartment of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Deborah M LevyDepartment of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Zia BismillaDepartment of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Shaun K MorrisDivision of Pediatric Infectious Diseases, The Hospital for Sick Children, Toronto, Canada.
Hospital for Sick Children · CAUniversity of Toronto · CAPublic Health Ontario · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 10-year-old boy with sickle cell disease (SCD) type SC presented with fever and abdominal pain after travel to Ghana and was diagnosed with Plasmodium falciparum infection. Despite adequate antimalarial treatment, he developed evidence of hyperinflammation with marked elevated ferritin, C-reactive protein, and triglycerides and subsequent bone marrow necrosis, characterized by elevated nucleated red blood cells and significant bone pain. This case report highlights the possible association between malaria and bone marrow necrosis in patients with SCD. Important considerations in treatment and workup of patients presenting with malaria and hyperinflammation are discussed.

Indexed as

Anemia, Sickle CellMalariaMalaria, FalciparumBone MarrowChildHumansMaleNecrosisPlasmodium falciparum

Identifiers

PMID37487563
PMCPMC10484272
OpenAlexW4385197338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.