Evidence map›Paper›PMID 37487226›Full record

ArticleACS chemical biology2023

Identification, Heterologous Expression, and Characterization of the Tolypodiol Biosynthetic Gene Cluster through an Integrated Approach.

Daniel Back, Timothy J O'Donnell, Kyle K Axt, Joshua R Gurr, Juan M Vanegas, Philip G Williams, Benjamin Philmus

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniel BackDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Timothy J O'DonnellDepartment of Chemistry, University of Hawai'i at Ma̅noa, Honolulu, Hawaii 96822, United States.
Kyle K AxtDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Joshua R GurrDepartment of Chemistry, University of Hawai'i at Ma̅noa, Honolulu, Hawaii 96822, United States.
Juan M VanegasDepartment of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, United States.
Philip G WilliamsDepartment of Chemistry, University of Hawai'i at Ma̅noa, Honolulu, Hawaii 96822, United States.ORCID 0000-0001-8987-0683
Benjamin PhilmusDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2085-0873
Oregon State University · USUniversity of Hawaiʻi at Mānoa · US

Funding

Research Training in Natural Product Complementary and Integrative Health - Diversity Supplement to T32 Predoctoral Training GrantT32AT010131 · NCCIH · OREGON STATE UNIVERSITY · PI TAIFO MAHMUD, RICHARD B VAN BREEMEN · 2020 to 2026
$1.8M
Acquisition of a 700 MHz NMR SpectrometerS10OD018518 · OD · OREGON STATE UNIVERSITY · PI BARBAR, ELISAR J · 2015 to 2015
$1.3M
Capture the Inhibitor: Affinity Approaches to the Discovery of Secretase LeadsR01AG039468 · NIA · UNIVERSITY OF HAWAII AT MANOA · PI WILLIAMS, PHILIP · 2011 to 2014
$1.1M
A workflow for identification of gene clusters and heterologous expression of cyanobacterial natural productsR15GM117541 · NIGMS · OREGON STATE UNIVERSITY · PI PHILMUS, BENJAMIN · 2016 to 2016
$422k
NCCIH NIH HHS T32 AT010131NIA NIH HHS R01 AG039468NIGMS NIH HHS R15 GM117541NIH HHS S10 OD018518
6 · The paper itself

Abstract

Cyanobacteria are tremendous producers of biologically active natural products, including the potent anti-inflammatory compound tolypodiol. However, linking biosynthetic gene clusters with compound production in cyanobacteria has lagged behind that in other bacterial genera. Tolypodiol is a meroterpenoid originally isolated from the cyanobacterium HT-58-2. Here we describe the identification of the tolypodiol biosynthetic gene cluster through heterologous expression in

Indexed as

Biological ProductsDiterpenesMethyltransferasesMultigene FamilyBiological ProductsDiterpenesMethyltransferasestolypodiol

Identifiers

PMID37487226
PMCPMC10529828
OpenAlexW4385221078

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.