Evidence map›Paper›PMID 37487098›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Nsp3-N interactions are critical for SARS-CoV-2 fitness and virulence.

Pengfei Li, Biyun Xue, Nicholas J Schnicker, Lok-Yin Roy Wong, David K Meyerholz, Stanley Perlman

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Structural Features of a Tiny Viral Protein, ORF7b of SARS-CoV-2.International journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Evolution of a fuzzy ribonucleoprotein complex in viral assembly.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.Protein science : a publication of the Protein Society · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Advances in the Search for SARS-CoV-2 MPathogens (Basel, Switzerland) · 2024
    Review
  20. Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pengfei LiDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.
Biyun XueDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242.
Nicholas J SchnickerProtein and Crystallography Facility, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-5189-4943
Lok-Yin Roy WongDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-0727-8289
David K MeyerholzDepartment of Pathology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0003-1552-3253
Stanley PerlmanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0003-4213-2354
University of Iowa · US

Funding

SARS-CoV Proteins in Heterologous Viral InfectionP01AI060699 · NIAID · UNIVERSITY OF IOWA · PI PERLMAN, STANLEY · 2004 to 2021
$21.5M
Role of eicosanoids in pathogenic human CoV infectionsR01AI129269 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 2016 to 2026
$4.7M
NIAID NIH HHS P01 AI060699NIAID NIH HHS R01 AI129269
6 · The paper itself

Abstract

SARS-CoV-2, the causative agent of COVID-19 encodes at least 16 nonstructural proteins of variably understood function. Nsp3, the largest nonstructural protein contains several domains, including a SARS-unique domain (SUD), which occurs only in

Indexed as

COVID-19Severe acute respiratory syndrome-related coronavirusAnimalsHumansMiceMutationSARS-CoV-2VirulenceN proteinnsp3SARS-CoV-2SARS-unique domain

Identifiers

PMID37487098
PMCPMC10400999
OpenAlexW4385191077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.