ArticleBioconjugate chemistry2023
Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers.
Article in Bioconjugate chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Rheological Modeling to Assess the Gelation Kinetics of Mono- and Multicomponent Supramolecular Hydrogels.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Synergistic Multicomponent Nucleopeptide-Based Hydrogels: Harnessing DNA-Base Pairing and Electrostatic Complementarities.ACS materials Au · 2026Article
- Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications.Advanced healthcare materials · 2025Review
- Self-Assembly of Heterochiral and Homochiral Peptides Conjugated to PNA Dimers and Their Integration in Peptide-Based Hydrogels.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nanostructural Modulation of G-Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches.Journal of neurochemistry · 2025Article
- Morphology and Applications of Self-Assembled Peptide Nucleic Acids.International journal of molecular sciences · 2024Review
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Authors and funding
6 authors.
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Abstract
Peptide nucleic acids and their conjugates to peptides can self-assemble and generate complex architectures. In this work, we explored the self-assembly of PNA dimers conjugated to the dipeptide WW. Our studies suggest that the indole ring of tryptophan promotes aggregation of the conjugates. The onset of fluorescence is observed upon self-assembly. The structure of self-assembled WWgc is concentration-dependent, being spherical at low concentrations and fibrous at high concentrations. As suggested by molecular modeling studies, fibers are stabilized by stacking interactions between tryptophans and Watson-Crick hydrogen bonds between nucleobases.
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