ArticlePloS one2023
Temporal trends in the disease burden of osteoarthritis from 1990 to 2019, and projections until 2030.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial.Scientific reports · 2025Trial
- Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions.Journal of orthopaedic surgery and research · 2024Trial
- Global burden of osteoarthritis attributable to high body mass index (1990-2021): rising trends with marked sex-age disparities and prediction to 2050.Clinical rheumatology · 2026Article
- Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation.Genes · 2026Article
- Targeted Intra-Articular PRGF Delivery Using Enzyme-Powered Nanobots for Chondral Lesions: A Prospective Experimental Study with Biomarker Evaluation in Rabbits (Animals : an open access journal from MDPI · 2026Article
- Integrated hydrogel system targeting AMPK/PPARγ signaling in osteoarthritis immunometabolic regulation.Journal of nanobiotechnology · 2026Article
- Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis.Exploration (Beijing, China) · 2026Review
- Review
- Efficacy and potential toxicity of Duhuo Qinjiao Decoction in osteoarthritis via the NF-κB pathway.Clinical rheumatology · 2026Article
- Context-dependent roles of 11β-HSD1 in bone and skeletal muscle diseases.American journal of translational research · 2026Review
- Automated Kellgren-Lawrence grading of knee osteoarthritis using a multi-scale attention-based deep learning framework.Frontiers in medicine · 2026Article
- Global prevalence, incidence, and years lived with disability (YLDs) of osteoarthritis: trends from 1990 to 2021 and projections to 2050.Journal of orthopaedic translation · 2026Article
- Positive association and shared genetic structure between cardiovascular diseases and osteoarthritis: Insights from cross-sectional study and genome-wide pleiotropic analysis.Therapeutic advances in musculoskeletal disease · 2026Article
- Real-world drug survival and treatment outcome of ixekizumab in patients with spondyloarthropathies.Frontiers in immunology · 2026Article
- Burden and Temporal Trends of Osteoarthritis in Germany from 1990 to 2021, with Projections to 2041: Findings from the Global Burden of Disease Study.Orthopedic research and reviews · 2026Article
- Longitudinal associations between bilateral versus unilateral knee osteoarthritis and physical performance measures.Osteoarthritis and cartilage open · 2025Article
- Study design and protocol of a randomized, pragmatic, comparative effectiveness trial evaluating a sequenced strategy for improving outcomes in people with knee osteoarthritis pain (SKOAP): Conservative treatment evaluation.Seminars in arthritis and rheumatism · 2025Article
- The Role of Myofascial Release Techniques as an Adjunct to Other Therapies in Knee Osteoarthritis: A Systematic Review.Health science reports · 2025Review
- Epidemiological trends of osteoarthritis at the global, regional, and national levels from 1990 to 2021 and projections to 2050.Arthritis research & therapy · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to report trends in the global burden of osteoarthritis (OA) from 1990 to 2019 and predict the trends in the following years based on Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The study included reporting on the prevalence and incidence rates, as well as disability-adjusted life years (DALYs). Additionally, the age-standardized incidence rate (ASR) and Estimated Annual Percent Change (EAPC) were analyzed along with related factors, finally, Bayesian age-period-cohort (BAPC) analysis were utilized to predict the trends in the upcoming years. In 2019, globally, there were about 414.7 million (95%UI: 368.8 to 464.4 million) OA incident cases, with an age-standardized incidence rate (ASR) about 492.21 (95% UI:438.66 to 551.5) per 100000. And there were about 527.8 million (95% UI: 478.7 to 584.8 million) OA prevalent cases in 2019. The DALYs for OA increased to about 189.49 million (95%UI: 95.71 to 376.60 million) from 1990 to 2019 (EAPC:0.14%; 95%CI: 0.12% to 0.16%). There was a positive association between ASR and Socio-demographic index (SDI) both at the regional and national level. BAPC results showed that ASR in females would decrease but increase in males in the following years. In conclusion, the global burden of OA has risen steadily between 1990 and 2019, placing a significant strain on society. This trend is expected to continue in the coming years. To alleviate this burden, it is necessary to implement measures that target risk factors such as high body mass index.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.