Evidence map›Paper›PMID 37486581›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2023

Dereplication of Lantana trifolia L. leaves and fruits by UFLC-DAD-(+)-ESI-MS/MS and its antifungal and cytotoxic activities.

Gáveni Barbosa Valério, Camila Capel Godinho, Thamires Rodrigues Freitas, Mariana Brentini Santiago, Daniel Oliveira Silva Martins, Ana Carolina Gomes Jardim, Leonardo Gobbo-Neto, Carlos Henrique Gomes Martins, Luís Carlos Scalon Cunha, Alan Cesar Pilon and 3 more

Open access · greenAbstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Gáveni Barbosa ValérioInstituto de Ciências Exatas, Naturais e Educação, Departamento de Química, Universidade Federal do Triângulo Mineiro, Uberaba, MG, 38064-200, Brazil.
Camila Capel GodinhoNPPNS - Núcleo de Pesquisa em Produtos Naturais e Sintéticos, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Monte Alegre, Ribeirão Preto, SP, 14040-903, Brazil.
Thamires Rodrigues FreitasNPCBio - Núcleo de Pesquisa em Compostos Bioativos, Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, MG, 38400-902, Brazil.
Mariana Brentini SantiagoLEA - Laboratório de Ensaios Antimicrobianos, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Uberlândia, MG, 38400-902, Brazil.
Daniel Oliveira Silva MartinsInstituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Uberlândia, MG, 38400-902, Brazil.
Ana Carolina Gomes JardimInstituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Uberlândia, MG, 38400-902, Brazil.
Leonardo Gobbo-NetoNPPNS - Núcleo de Pesquisa em Produtos Naturais e Sintéticos, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, Monte Alegre, Ribeirão Preto, SP, 14040-903, Brazil.
Carlos Henrique Gomes MartinsLEA - Laboratório de Ensaios Antimicrobianos, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará 1720, Uberlândia, MG, 38400-902, Brazil.
Luís Carlos Scalon CunhaNuBiProN - Núcleo de Bioprospecção em Produtos Naturais, Departamento de Química, Instituto Federal do Triângulo Mineiro, Av. João Batista Ribeiro 4000, Uberaba, MG, 38064-790, Brazil.
Alan Cesar PilonNuBBE - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Universidade Estadual Paulista, Rua Francisco Degni, 55, Jardim Quitandinha, Araraquara, SP, 14800-900, Brazil.
Aline CoqueiroDepartamento de Química, Universidade Tecnológica Federal do Paraná, Rua Doutor Washington Subtil Chueire, 330, Jardim Carvalho, Ponta Grossa, PR, 84017-220, Brazil.
Marcos PivattoNPCBio - Núcleo de Pesquisa em Compostos Bioativos, Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, MG, 38400-902, Brazil.
Amanda DanuelloInstituto de Ciências Exatas, Naturais e Educação, Departamento de Química, Universidade Federal do Triângulo Mineiro, Uberaba, MG, 38064-200, Brazil. danuello@ufu.br.
Universidade Federal de Uberlândia · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BRUniversidade Federal do Triângulo Mineiro · BRUniversidade Tecnológica Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLantana trifolia L. (Verbenaceae) is a shrubby plant. In folk medicine, its leaves are used in the form of infusions and syrups to treat angina, coughs, and colds; they are also applied as tranquilizer. Previous studies have reported the antimicrobial potential of the compounds present in L. trifolia leaves.

objectivesTo report the anti-Candida activities of the fractions obtained from the fruits and leaves of two L. trifolia specimens.

methodsThe L. trifolia fractions were submitted to UFLC-DAD-(+)-ESI-MS/MS, and the data were analyzed by using multivariate statistical tools (PCA, PLS-DA) and spectral similarity analyses based on molecular networking, which aided dereplication of the bioactive compounds. Additionally, NMR analyses were performed to confirm the chemical structure of some of the major compounds in the fractions.

resultsThe ethyl acetate fractions presented MIC values lower than 100 µg mL

conclusionOn the basis of our data, the most active fractions in the antifungal assay were more selective against C. glabrata than against non-infected cells. The analytical approach adopted here allowed us to annotate 29 compounds, nine of which were bioactive (PLS-DA results) and belong to the class of phenolic compounds.

Indexed as

Antineoplastic AgentsLantanaAntifungal AgentsFruitMetabolomicsPlant ExtractsPlant LeavesTandem Mass SpectrometryAntifungal AgentsAntineoplastic AgentsPlant ExtractsAnti-CandidaLantana trifolia L.Molecular networkingNatural products

Identifiers

PMID37486581
OpenAlexW4385185812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.