ArticleAdvances in experimental medicine and biology2023
Computational Methods for Protein Tertiary Structure Analysis.
Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Protein folding accuracy is fundamental to all cells. In spite of this, it is difficult to maintain the fidelity of protein synthesis and folding due to the fact that the implicit genetic and biochemical systems are inherently prone to error, which leads to the constant production of a certain amount of misfolded proteins. This problem is further compounded by genetic variation and the effects of environmental stress. To that end, the prediction of protein structures for tertiary protein structure analysis and prediction might be an ideal approach for the study of mutation effects in macromolecules and their complexes. With the development and accessibility to increasingly powerful computational systems, this type of study will enable a wide variety of opportunities for the creation of better-targeted peptide-based pharmacotherapy and prospects for precision medicine in future.
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