ArticleeLife2023
Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Quantifying the spatiotemporal mechanical dynamics of engineered cardiac microbundles.PLoS computational biology · 2026Article
- Spectral dependence as a framework for neural coordination.Current research in neurobiology · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Article
- Increased Perceptual Reliability Reduces Membrane Potential Variability in Cortical Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
- A genetic algorithm for self-supervised models of oscillatory neurodynamics.bioRxiv : the preprint server for biology · 2025Article
- Layers of the monkey visual cortex are selectively modulated during electrical stimulation.PLoS biology · 2025Article
- Cortical dynamics of neural-connectivity fields.Journal of computational neuroscience · 2025Article
- Single Neuron Contributions to the Auditory Brainstem EEG.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Python toolbox for neural circuit parameter inference.NPJ systems biology and applications · 2025Article
- BlueRecording: A pipeline for the efficient calculation of extracellular recordings in large-scale neural circuit models.PLoS computational biology · 2025Article
- Integrating multimodal data to understand cortical circuit architecture and function.Nature neuroscience · 2025Review
- On the validity of electric brain signal predictions based on population firing rates.PLoS computational biology · 2025Article
- Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis.PLoS computational biology · 2024Article
- Reconciliation of weak pairwise spike-train correlations and highly coherent local field potentials across space.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Multitask learning of a biophysically-detailed neuron model.PLoS computational biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Local field potential (LFP) recordings reflect the dynamics of the current source density (CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and sources are ill-understood. We investigated these in mouse primary visual cortex using public Neuropixels recordings and a detailed circuit model based on simulating the Hodgkin-Huxley dynamics of >50,000 neurons belonging to 17 cell types. The model simultaneously captured spiking and CSD responses and demonstrated a two-way dissociation: firing rates are altered with minor effects on the CSD pattern by adjusting synaptic weights, and CSD is altered with minor effects on firing rates by adjusting synaptic placement on the dendrites. We describe how thalamocortical inputs and recurrent connections sculpt specific sinks and sources early in the visual response, whereas cortical feedback crucially alters them in later stages. These results establish quantitative links between macroscopic brain measurements (LFP/CSD) and microscopic biophysics-based understanding of neuron dynamics and show that CSD analysis provides powerful constraints for modeling beyond those from considering spikes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.