ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Frailty Among Sexual and Gender Minority Older Adults: The All of Us Database.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- American Geriatrics Society Position Statement: Advancing the Healthcare of Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, and More Older Adults.Journal of the American Geriatrics Society · 2026Article
- The Mediating Role of Frailty in Healthcare Utilization Among Sexual and Gender Minorities: A Comparison of Generalist, Specialist, and Mental Health Visits.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Frailty and Physical Activity: A Compositional Isotemporal Substitution Analysis from the All of Us Research Program.Journal of frailty, sarcopenia and falls · 2025Article
- Identification of Transgender and Gender-Diverse Individuals in the All of Us Research Program, 2017-2022.American journal of public health · 2025Article
- Assessing how frailty and healthcare delays mediate the association between sexual and gender minority status and healthcare utilization in the All of Us Research Program.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Advancing Aging Research Through a Health Disparities Perspective.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Factors Associated with Frailty in Older Adults in Community and Nursing Home Settings: A Systematic Review with a Meta-Analysis.Journal of clinical medicine · 2024Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundDespite known disparities in health status among older sexual and gender minority adults (OSGM), the prevalence of frailty is unknown. The aim of this study was to develop and validate a deficit-accumulation frailty index (AoU-FI) for the All of Us database to describe and compare frailty between OSGM and non-OSGM participants.
methodsDeveloped using a standardized approach, the AoU-FI consists of 33 deficits from baseline survey responses of adults aged 50+. OSGM were self-reported as "not straight" or as having discordant gender and sex assigned at birth. Descriptive statistics characterized the AoU-FI. Regression was used to assess the association between frailty, age, and gender. Validation of the AoU-FI used Cox proportional hazard models to test the association between frailty categories (robust <0.15, 0.15 ≤ pre-frail ≤ 0.25, frail >0.25) and mortality.
resultsThere were 9 110 OSGM and 67 420 non-OSGM with sufficient data to calculate AoU-FI; 41% OSGM versus 50% non-OSGM were robust, whereas 34% versus 32% were pre-frail, and 26% versus 19% were frail. Mean AoU-FI was 0.19 (95% confidence interval [CI]: 0.187, 0.191) for OSGM and 0.168 (95% CI: 0.167, 0.169) for non-OSGM. Compared to robust, odds of mortality were higher among frail OSGM (odds ratio [OR] 6.40; 95% CI: 1.84, 22.23) and non-OSGM (OR 3.96; 95% CI: 2.96, 5.29).
conclusionsThe AoU-FI identified a higher burden of frailty, increased risk of mortality, and an attenuated impact of age on frailty among OSGM compared to non-OSGM. Future work is needed to understand how frailty affects the OSGM population.
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