ArticleFrontiers in nutrition2023
Association between ultra-processed food intake and risk of colorectal cancer: a systematic review and meta-analysis.
Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Ultra-Processed Food Consumption and Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of food science · 2026Pooled it
- Ultra-processed food intake and risk of digestive system cancers: a systematic review and dose-response meta-analysis.Frontiers in nutrition · 2026Pooled it
- Dietary total antioxidant capacity and risk of stroke: a systematic review and dose-response meta-analysis of observational studies.Frontiers in nutrition · 2024Pooled it
- Ultra-processed foods consumption and health-related outcomes: a systematic review of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Ultra-processed food consumption and chronic kidney disease risk: a systematic review and dose-response meta-analysis.Frontiers in nutrition · 2024Pooled it
- Assessing the role of ultra-processed foods in colorectal cancer incidence: insights from the EPIC cohort.BMC public health · 2026Article
- Global, regional and national burden of colorectal cancer attributable to low-fiber diet from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in nutrition · 2026Article
- Post-diagnostic ultra-processed food exposure in gastrointestinal cancers: scoping review with narrative synthesis and clinical implications.Frontiers in nutrition · 2026Review
- Intake of total and selected carotenoids and colorectal cancer risk: An Italian case-control study.European journal of clinical nutrition · 2025Article
- Food Preservatives and the Rising Tide of Early-Onset Colorectal Cancer: Mechanisms, Controversies, and Emerging Innovations.Foods (Basel, Switzerland) · 2025Review
- The association between ultra-processed foods intake and the odds of prostate cancer: a case-control study.Journal of health, population, and nutrition · 2025Article
- Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer.Current oncology reports · 2025Review
- Ultra-processed food, obesity, and colon cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2025Article
- Ultra-processed foods and food additives in gut health and disease.Nature reviews. Gastroenterology & hepatology · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although some epidemiological studies have shown a positive relationship between high intake of ultra-processed food (UPF) and risk of colorectal cancer (CRC), the results remain inconsistent. Therefore, we conducted this systematic review and meta-analysis to clarify the association between UPF intake and CRC risk. Methods: PubMed/MEDLINE, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI) and Wan fang databases were used to search the relevant studies published up to February 2023. The summary relative risks (RRs) with the corresponding 95% confidence intervals (CIs) were estimated by comparing the highest category vs. the lowest category of UPF intake, using the random-effects models (DerSimonian-Laird method). Heterogeneity between studies was explored using the Cochran's Q test and I-square (I Results: A total of seven articles (three cohort and four case-control studies), involving 18,673 CRC cases and 462,292 participants, were included in our study. Combining nine effect sizes from seven articles, an increased risk of CRC was shown in the highest compared with the lowest category of UPF intake (RR = 1.26; 95%CI:1.14-1.38, Conclusion: Our results show that high UPF intake is significantly associated with a higher risk of CRC, in the absence, however, of a dose-response association. Further studies in particular of large prospective cohort studies are necessary to confirm these results.
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