Evidence map›Paper›PMID 37485388›Full record

ArticleFrontiers in nutrition2023

Effects of

Eliska Jenickova, Carin Andrén Aronsson, Anna Mascellani Bergo, Ondrej Cinek, Jaroslav Havlik, Daniel Agardh

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03176095 (Celiac Disease Prevention With Probiotics), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03176095 nacompletednot on this map

Celiac Disease Prevention With Probiotics

TypeinterventionalSponsorLund UniversityRan2012 to 2015Enrolled90ConditionsCeliac Disease in ChildrenArmsProbiotic, Placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Intake ofNutrients · 2023
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. PhytochemicalOpen biology · 2024
    Article
  8. Review
  9. Probiotics to Prevent Celiac Disease and Inflammatory Bowel Diseases.Advances in experimental medicine and biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Eliska JenickovaDepartment of Food Science, Czech University of Life Sciences Prague, Prague, Czechia.
Carin Andrén AronssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Anna Mascellani BergoDepartment of Food Science, Czech University of Life Sciences Prague, Prague, Czechia.
Ondrej CinekDepartment of Pediatrics and Department of Medical Microbiology, Charles University in Prague and University Hospital Motol, Prague, Czechia.
Jaroslav HavlikDepartment of Food Science, Czech University of Life Sciences Prague, Prague, Czechia.
Daniel AgardhDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Czech University of Life Sciences Prague · CZLund University · SECharles University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and gluten intake, however, may play a role in triggering the disease. The gut internal environment is thought to be one of these potential contributing factors, and it can be influenced throughout life. Methods: We examine the impact of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 supplementation on the faecal metabolome in genetically predisposed children having tissue transglutaminase autoantibodies, i.e., coeliac disease autoimmunity. Probiotic strains were selected based on their beneficial properties, including mucosal permeability and immune modulation effects. The intervention group ( Results: During the 6 months of intervention, the stool concentrations of 4-hydroxyphenylacetate increased in the intervention group as compared to controls, whereas concentrations of threonine, valine, leucine, isoleucine, methionine, phenylalanine, aspartate, and fumarate decreased. Additionally, a noteworthy effect on the glycine, serine, and threonine metabolic pathway has been observed. Conclusion: The findings suggest a modest yet significant impact of the probiotics on the faecal metabolome, primarily influencing proteolytic processes in the gut. Clinical trial registration: ClinicalTrials.gov, NCT03176095.

Indexed as

coeliac diseasegut metabolomeLacticaseibacillus paracaseiLactiplantibacillus plantarumNMRprobiotics

Identifiers

PMID37485388
PMCPMC10359497
OpenAlexW4383314137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.