ArticleFrontiers in cardiovascular medicine2023
The value of left atrial longitudinal strain in evaluating left atrial appendage spontaneous echo contrast in non-valvular atrial fibrillation.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Evaluation of myocardial function by strain echocardiography in cats with hypertrophic cardiomyopathy phenotypes.Veterinary world · 2026Article
- Development of a nomogram with machine learning-assisted feature selection for predicting left atrial appendage thrombosis and severe spontaneous echo contrast in patients with non-paroxysmal atrial fibrillation.BMC cardiovascular disorders · 2026Article
- Transthoracic signs of left atrial cardiomyopathy predict presence of left atrial thromboembolic substrate.Heart rhythm O2 · 2026Article
- Left atrial strain in patients without cardiovascular disease: uncovering influencing and related factors.Cardiovascular ultrasound · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Background: Spontaneous echo contrast (SEC) observed in transesophageal echocardiography (TEE) is a reliable predictor of the risk of future ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). Left atrial strain globally reflects atrial function, remodeling and distensibility. The left atrial appendage (LAA) is a myogenic remnant of the left atrium, which can actively relax and contract. The left atrial appendage (LAA) is an important part of releasing the pressure of the left atrium. The key role of the left atrium is to regulate the left ventricular filling pressure, act as a reservoir for pulmonary venous return during ventricular contraction, and act as a conduit, transferring blood to the Left ventricle during early ventricular diastole. The purpose of this study was to explore the relationship between left atrial function and left atrial appendage spontaneous echo contrast (LAASEC). Methods: A retrospective study of 338 patients with non-valvular AF was conducted. Two-dimensional speckle-tracking echocardiography provided the following metrics of LA strain: LA strain during the reservoir phase (LASr), LA strain during the conduit phase (LAScd). LA or LAA has the dense SEC of more than grade 3, which is defined as mud like change or pre thrombosis. Results: Patients with level 3 SEC ( Conclusion: Lower LASr is independently associated with the dense LAASEC in NVAF and has incremental values superior to clinical scores. The decrease of LASr may be a potential non-invasive parameter for evaluating the higher risk of LAA thrombosis.
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