Evidence map›Paper›PMID 37485033›Full record

ArticleOncoimmunology2023

CD11c

Benita C Y Tse, Sarah Bergamin, Pascal Steffen, George Hruby, Nick Pavlakis, Stephen J Clarke, Justin Evans, Alexander Engel, Andrew Kneebone, Mark P Molloy

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A laminin α4-CD8Oncoimmunology · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Benita C Y TseBowel Cancer and Biomarker Laboratory, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Sarah BergaminDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, Australia.
Pascal SteffenBowel Cancer and Biomarker Laboratory, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
George HrubyDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, Australia.
Nick PavlakisDepartment of Medical Oncology, Royal North Shore Hospital, Sydney, Australia.
Stephen J ClarkeDepartment of Medical Oncology, Royal North Shore Hospital, Sydney, Australia.
Justin EvansColorectal Surgical Unit, Royal North Shore Hospital, Sydney, Australia.
Alexander EngelSydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
Andrew KneeboneDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, Australia.
Mark P MolloyBowel Cancer and Biomarker Laboratory, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.ORCID https://orcid.org/0000-0003-4679-5868
The University of Sydney · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 20% of locally advanced rectal cancer (LARC) patients treated preoperatively with chemoradiotherapy (CRT) achieve pathologically confirmed complete regression. However, there are no clinically implemented biomarkers measurable in biopsies that are predictive of tumor regression. Here, we conducted multiplexed immunophenotyping of rectal cancer diagnostic biopsies from 16 LARC patients treated preoperatively with CRT. We identified that patients with greater tumor regression had higher tumor infiltration of pan-T cells and IRF8

Indexed as

CD11c AntigenInterferon Regulatory FactorsRectal NeoplasmsT-LymphocytesAgedBiomarkersBiopsyCell CountFemaleHumansInterferon Regulatory Factor-8MaleMiddle AgedNeoadjuvant TherapyPredictive Value of TestsTreatment OutcomeBiomarkersCD11c AntigenInterferon Regulatory Factor-8Interferon Regulatory FactorsDendritic cellimmune cellimmunophenotypeneoadjuvant chemoradiotherapyrectal cancer

Identifiers

PMID37485033
PMCPMC10361136
OpenAlexW4384925239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.