Evidence map›Paper›PMID 37484938›Full record

SynthesisFrontiers in endocrinology2023

Mesenchymal stem cells therapy improves ovarian function in premature ovarian failure: a systematic review and meta-analysis based on preclinical studies.

Congcong Guo, Yubo Ma, Yanqiu Situ, Li Liu, Guoqun Luo, Huan Li, Wenmin Ma, Li Sun, Wen Wang, Qiuying Weng and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  6. [Stem cell therapy for premature ovarian insufficiency: a review of clinical evidence and therapeutic strategies].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Congcong GuoReproductive Medicine Center, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Yubo MaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Yanqiu SituReproductive Medicine Center, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Li LiuDepartment of Library, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Guoqun LuoReproductive Medicine Center, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Huan LiReproductive Medicine Center, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Wenmin MaReproductive Medical Center, Zhaoqing Westriver Hospital, Zhaoqing, Guangdong, China.
Li SunDepartment of Library, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Wen WangDepartment of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Qiuying WengReproductive Medicine Center, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Linlin WuDepartment of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Dazhi FanDepartment of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong, China.
Foshan Maternity and Child Health Care Hospital · CNAnhui Medical University · CNZhaoqing University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have revealed that the transplantation of mesenchymal stem cells (MSCs) might be a potential star candidate for premature ovarian failure (POF) in animal experiments. However, individual studies with a small sample size cannot be used to draw a clear conclusion. Therefore, we conducted a systematic review and meta-analysis to explore the potential of using MSCs in the treatment of POF in animals. Methods: Seven databases were searched for studies exploring the effect of the transplantation of MSCs on POF in animal models. The PRISMA guideline was followed, and the methodological quality was ensured using SYRCLE's risk of bias tool. RevMan 5.4 and STATA 12.0 software was performed to meta-analysis. Results: In total, 37 studies involving 1,079 animals were included. Significant associations were found for MSCs with the levels of E2 (SMD 2.69 [95% CI 1.97, 3.41]), FSH (-2.02, [-2.74, -1.30]), primary follicles (2.04, [1.17, 2.92]), secondary follicles (1.93, [1.05, 2.81]), and primordial follicles (2.38, [1.19, 3.57]. Other outcomes, such as AMH, LH, INHB, antral follicles, growing follicles, mature follicles, and early antral were also found to be significant. There was no difference in FSH/LH, corpus leteum, follicles, and estruc cycle. Conclusions: Our meta-analysis result indicated that the transplantation of MSCs might exert therapeutic effects on animal models of POF, and these effects might be associated with improving the disorder of the sexual cycle, modulating serum hormone expressions to a better state, and restoring ovarian function.

Indexed as

Menopause, PrematureMesenchymal Stem CellsPrimary Ovarian InsufficiencyAnimalsFemaleFollicle Stimulating HormoneHumansOvarian FollicleFollicle Stimulating Hormonefertilitymesenchymal stem cellsmeta-analysisovarian functionpremature ovarian failure

Identifiers

PMID37484938
PMCPMC10361781
OpenAlexW4383314528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.