Evidence map›Paper›PMID 37484879›Full record

ArticleTrends in analytical chemistry : TRAC2023

Recent Review on Selected Xenobiotics and Their Impacts on Gut Microbiome and Metabolome.

Yan Jin, Jinhua Chi, Kaelene LoMonaco, Alexandria Boon, Haiwei Gu

Open access · greenAbstract read
In one paragraph

Article in Trends in analytical chemistry : TRAC, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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  8. Anti-Obesity and Metabolic Effects of Forskolin in Obese C57BL/6J Mice.International journal of molecular sciences · 2025
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  12. Review
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  15. Artificial Intelligence in Metabolomics: A Current Review.Trends in analytical chemistry : TRAC · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yan JinCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Jinhua ChiCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Kaelene LoMonacoCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Alexandria BoonCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Haiwei GuCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Florida International University · US

Funding

TGF-ß-SOX18-Collagen metabolism in pulmonary vascular disease associated with CHDP01HL146369 · NHLBI · UNIVERSITY OF ARIZONA · PI JEFFREY R FINEMAN · 2020 to 2026
$18.7M
Developmental PBDE exposure, gut microbiome, and diabetesR01ES030197 · NIEHS · UNIVERSITY OF WASHINGTON · PI Julia Yue Cui, Haiwei Gu · 2019 to 2026
$5.0M
NHLBI NIH HHS P01 HL146369NIEHS NIH HHS R01 ES030197
6 · The paper itself

Abstract

As it is well known, the gut is one of the primary sites in any host for xenobiotics, and the many microbial metabolites responsible for the interactions between the gut microbiome and the host. However, there is a growing concern about the negative impacts on human health induced by toxic xenobiotics. Metabolomics, broadly including lipidomics, is an emerging approach to studying thousands of metabolites in parallel. In this review, we summarized recent advancements in mass spectrometry (MS) technologies in metabolomics. In addition, we reviewed recent applications of MS-based metabolomics for the investigation of toxic effects of xenobiotics on microbial and host metabolism. It was demonstrated that metabolomics, gut microbiome profiling, and their combination have a high potential to identify metabolic and microbial markers of xenobiotic exposure and determine its mechanism. Further, there is increasing evidence supporting that reprogramming the gut microbiome could be a promising approach to the intervention of xenobiotic toxicity.

Indexed as

Gut MicrobiomeLipidomicsMass SpectrometryMetabolic Flux AnalysisMetabolomicsXenobiotic Exposure

Identifiers

PMID37484879
PMCPMC10361410
OpenAlexW4382405082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.