Evidence map›Paper›PMID 37484823›Full record

ReviewFrontiers in cellular neuroscience2023

Preserving and enhancing mitochondrial function after stroke to protect and repair the neurovascular unit: novel opportunities for nanoparticle-based drug delivery.

Robyn J Novorolsky, Gracious D S Kasheke, Antoine Hakim, Marianna Foldvari, Gabriel G Dorighello, Israel Sekler, Vidyasagar Vuligonda, Martin E Sanders, Robert B Renden, Justin J Wilson and 1 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07651787 (Neurovascular and Mitochondrial Mechanisms of Transcranial Photobiomodulation in Vascular Mild Cognitive Impairment), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07651787 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neurovascular and Mitochondrial Mechanisms of Transcranial Photobiomodulation in Vascular Mild Cognitive Impairment

TypeinterventionalSponsorUniversity of OklahomaRan2025 to 2026Enrolled40ConditionsMild Cognitive Impairment (MCI), Amyloid PathologyArmsActive Vielight Neuro RX-Duo device -Active transcranial photobiomodulation, Sham Vielight Neuro RX-Duo device -Sham transcranial photobiomodulation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. The role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.Journal of bioenergetics and biomembranes · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Mitochondrial CaCell calcium · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Robyn J NovorolskyDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Gracious D S KashekeDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Antoine HakimSchool of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.
Marianna FoldvariSchool of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.
Gabriel G DorighelloDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben Gurion University, Beersheva, Israel.
Vidyasagar VuligondaIo Therapeutics, Houston, TX, United States.
Martin E SandersIo Therapeutics, Houston, TX, United States.
Robert B RendenDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, United States.
Justin J WilsonDepartment of Chemistry and Chemical Biology, College of Arts and Sciences, Cornell University, Ithaca, NY, United States.
George S RobertsonDepartment of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Dalhousie University · CAUniversity of Waterloo · CABen-Gurion University of the Negev · ILFlorida State University · USUniversity of Nevada, Reno · US

Funding

Activity-dependent energy homeostasis at the presynaptic terminalR01NS117686 · NINDS · UNIVERSITY OF NEVADA RENO · PI RENDEN, ROBERT B · 2020 to 2022
$1.6M
NINDS NIH HHS R01 NS117686
6 · The paper itself

Abstract

The neurovascular unit (NVU) is composed of vascular cells, glia, and neurons that form the basic component of the blood brain barrier. This intricate structure rapidly adjusts cerebral blood flow to match the metabolic needs of brain activity. However, the NVU is exquisitely sensitive to damage and displays limited repair after a stroke. To effectively treat stroke, it is therefore considered crucial to both protect and repair the NVU. Mitochondrial calcium (Ca

Indexed as

mitochondrial calcium uniporterneurovascular unitretinoid X receptorsodium/calcium/lithium exchangerstrokethyroid hormone receptor

Identifiers

PMID37484823
PMCPMC10360135
OpenAlexW4383554690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.