Evidence map›Paper›PMID 37484485›Full record

ArticleResearch in human development2023

Transgenerational effect of Mothers' experiences of discrimination on Black youths' hormone coupling in response to laboratory stress.

Shannin N Moody, Jenny M Phan, Elizabeth A Shirtcliff, Wen Wang, Stacy Drury, Katherine Theall

Abstract read
In one paragraph

Article in Research in human development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shannin N MoodyDepartment of Neurology, Louisiana State University Health Sciences Center, New Orleans (LA), USA.
Jenny M PhanCenter for Autism Spectrum Disorders, Children's National Hospital, Washington (D.C.) USA.
Elizabeth A ShirtcliffCenter for Translational Neuroscience, Department of Psychology, University of Oregon, Eugene (OR), USA.
Wen WangCenter for Translational Neuroscience, Department of Psychology, University of Oregon, Eugene (OR), USA.
Stacy DruryDepartment of Pediatrics, Tulane University, New Orleans, (LA), USA.
Katherine TheallDepartments of Social, Behavioral, and Population Sciences and Epidemiology, Tulane University, New Orleans, (LA), USA.

Funding

Translational Research/Education ComponentP60AA009803 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PATRICIA E. MOLINA · 2004 to 2026
$42.6M
Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
PILOT--IMPACT OF ALCOHOLISM ON AIDS ASOCIATED MUSCLE WASTINGP50AA009803 · NIAAA · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI NELSON, STEVE · 1994 to 2003
$7.2M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Setting the trajectoryR01MH101533 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2013 to 2017
$2.7M
District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32)T32NS115656 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI BERL, MADISON MEHALANI, SIDOROV, MICHAEL S · 2021 to 2025
$1.8M
Telomere Length as a Biological Marker of Allostatic Load in ChildrenR01ES020447 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI THEALL, KATHERINE P · 2011 to 2012
$877k
Telomeres as an Epigenetic Marker of Neurodevelopment and Early AdversityR21MH094688 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2011 to 2012
$414k
Molecular Regulation of UreagenesisK01DK076846 · NIDDK · CHILDREN'S RESEARCH INSTITUTE · PI CALDOVIC, LJUBICA MORIZONO · 2008 to 2010
$323k
Stress Biology and Psychosocial stressors as mechanisms for Racial Health Disparities in Neural and Clinical Impairments of Multiple SclerosisK00NS125815 · NINDS · LSU HEALTH SCIENCES CENTER · PI MOODY, SHANNIN NICOLE · 2023 to 2025
$217k
NIAAA NIH HHS P60 AA009803NICHD NIH HHS L40 HD106312NICHD NIH HHS P50 HD105328NICHD NIH HHS P50 HD105353NICHD NIH HHS T32 HD007489NICHD NIH HHS U54 HD090256NIDDK NIH HHS K01 DK076846NIEHS NIH HHS R01 ES020447NIMH NIH HHS F31 MH118853NIMH NIH HHS R01 MH101533NIMH NIH HHS R21 MH094688NINDS NIH HHS F99 NS125815NINDS NIH HHS K00 NS125815NINDS NIH HHS T32 NS115656
6 · The paper itself

Abstract

Exposure to pervasive racial discrimination of Black Americans is transgenerational in that mothers' experiences of discriminatory violence impacts their children. This study explored whether stress-related biomarkers reflect transgenerational racial stress by implementing a "dual activation" framework to probe how adrenal and gonadal hormones underlying adolescent development are co-regulated during a laboratory stressor. Data were collected from 120 Black families in the United States. Children completed the Trier Social Stress Task (TSST-C) and provided 4 saliva samples across 2 days that were assayed for cortisol (C), dehydroepiandrosterone (DHEA), and testosterone (T). Mothers reported their experiences of total discrimination and racial discrimination related to skin color/race. Thirty four percent reported experiences of discrimination and on average 46.7% reported experiences of discrimination due to their race or skin tone. Mothers' experiences of racial discrimination were associated with their child's hormonal reactivity to and recovery from the TSST-C. Youth showed stronger positive hormone coupling between C-T if their mother experienced greater discrimination. Mothers' experiences of racial discrimination influenced both C-T coupling and youths' cortisol recovery from the TSST-C. For youths with high testosterone, cortisol recovery was blunted. Results suggest that associations between racism and hormonal stress response may be transgenerational. Mothers' experiences of discrimination had a profound impact on their children's hormonal co-regulation.

Indexed as

cortisolDHEAhormone couplingracial discriminationtestosteronetransgenerational stress

Identifiers

PMID37484485
PMCPMC10358998

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.