Evidence map›Paper›PMID 37484028›Full record

ArticleJAC-antimicrobial resistance2023

Impact of antimicrobial use on abundance of antimicrobial resistance genes in chicken flocks in Vietnam.

Nguyen Thi Nhung, Avijit Dutta, Ellen Higginson, Leanne Kermack, Nguyen Thi Phuong Yen, Doan Hoang Phu, Bach Tuan Kiet, Marc Choisy, Ronald B Geskus, Stephen Baker and 1 more

Open access · goldAbstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Nguyen Thi NhungOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0002-6167-3976
Avijit DuttaCambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.
Ellen HigginsonCambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.
Leanne KermackCambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.
Nguyen Thi Phuong YenOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Doan Hoang PhuOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Bach Tuan KietSub-Department of Animal Health and Production, Dong Thap Province, Cao Lanh, Vietnam.
Marc ChoisyOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0002-5187-6390
Ronald B GeskusOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Stephen BakerCambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.
Juan Carrique-MasOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0001-9161-8890
University of Cambridge · GBOxford University Clinical Research Unit · VNUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Objectives: We investigated longitudinally Vietnamese small-scale chicken flocks in order to characterize changes in antimicrobial resistance gene (ARG) content over their life cycle, and the impact of antimicrobial use (AMU) on an intervention consisting of veterinary advice provision. Methods: AMU data and faecal samples were collected from 83 flocks (25 farms) at day-old, mid- and late-production (∼4 month cycle). Using high-throughput real-time PCR, samples were investigated for 94 ARGs. ARG copies were related to 16S rRNA and ng of DNA (ngDNA). Impact of AMU and ARGs in day-olds was investigated by mixed-effects models. Results: Flocks received a mean (standard error, SE) animal daily dose (ADD) of 736.7 (83.0) and 52.1 (9.9) kg in early and late production, respectively. Overall, ARGs/16S rRNA increased from day-old (mean 1.47; SE 0.10) to mid-production (1.61; SE 0.16), further decreasing in end-production (1.60; SE 0.1) (all Conclusions: The flocks' environment (contaminated water, feed and residual contamination) is likely to play a more important role in transmission of ARGs to flocks than previously thought. Results highlight intriguing differences in the quantification of ARGs depending on the metric chosen.

Identifiers

PMID37484028
PMCPMC10362913
OpenAlexW4385186312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.