Evidence map›Paper›PMID 37483767›Full record

ReviewHeliyon2023

3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities.

Abdullah Aldhaher, Fahimeh Shahabipour, Abdullah Shaito, Saphwan Al-Assaf, Ahmed A M Elnour, El Bashier Sallam, Shahin Teimourtash, Abdelgadir A Elfadil

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Application and prospects of nanomaterials in osteoporosis treatment.International journal of pharmaceutics: X · 2026
    Review
  3. Article
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  14. Frontiers in cell and developmental biology · 2025
    Article
  15. Article
  16. [Research progress in repair and reconstruction of tumor-related bone defects in proximal femur].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
  17. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdullah AldhaherDepartment of Chemistry, Faculty of Chemistry, Sharif University of Technology, Tehran, Iran.
Fahimeh ShahabipourOrthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran.
Abdullah ShaitoBiomedical Research Center, College of Medicine, And Department of Biomedical Sciences at College of Health Sciences, Qatar University, P.O. Box 2713, Doha, Qatar.
Saphwan Al-AssafHydrocolloids Research Centre, University of Chester, Chester, United Kingdom.
Ahmed A M ElnourFaculty of Chemical and Process Engineering Technology, University of Malaysia Pahang-UMP, Malaysia.
El Bashier SallamFreelance Global and Public Health Expert (FGPHE), Sudan.
Shahin TeimourtashDepartment of Healthcare Science Center, McMaster University, Toronto, Canada.
Abdelgadir A ElfadilDepartment of Environmental Science, Faculty of Science and Technology, Al-Neelain University, P. O. Box: 12702, Sudan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials.

Indexed as

3D scaffoldBioactive glassesIon-doped hydrogel scaffoldVascularized bone

Identifiers

PMID37483767
PMCPMC10362084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.