Evidence map›Paper›PMID 37483649›Full record

ArticleCurrent opinion in electrochemistry2023

Electrochemical point-of-care devices for the diagnosis of sepsis.

Enrique Valera, Victoria Kindratenko, Aaron M Jankelow, John Heredia, Alicia Y Kim, Thomas W Cowell, Chih-Lin Chen, Karen White, Hee-Sun Han, Rashid Bashir

Open access · greenAbstract read
In one paragraph

Article in Current opinion in electrochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. A concise overview of advancements in ultrasensitive biosensor development.Frontiers in bioengineering and biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Enrique ValeraDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Victoria KindratenkoDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Aaron M JankelowDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
John HerediaDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Alicia Y KimDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Thomas W CowellDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Chih-Lin ChenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Karen WhiteDepartment of Biomedical and Translation Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Hee-Sun HanDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Rashid BashirDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
University of Illinois Urbana-Champaign · USCarle Foundation Hospital · US

Funding

The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
Point-of-Care Microfluidic Biochip for Biomarkers Monitoring for Contributing in Early Sepsis DiagnosisR01AI148385 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID · 2021 to 2024
$2.1M
NIAID NIH HHS R01 AI148385NIBIB NIH HHS P41 EB031772
6 · The paper itself

Abstract

Sepsis is a life-threatening dysfunction of organ systems caused by a dysregulated immune system because of an infectious process. It remains one of the leading causes of hospital mortality and of hospital readmissions in the United States. Mortality from sepsis increases with each hour of delayed treatment, therefore, diagnostic devices that can reduce the time from the onset of a patient's infection to the delivery of appropriate therapy are urgently needed. Likewise, tools that are capable of high-frequency testing of clinically relevant biomarkers are required to study disease progression. Electrochemical biosensors offer important advantages such as high sensitivity, fast response, miniaturization, and low cost that can be adapted to clinical needs. In this review paper, we discuss the current state, limitations, and future directions of electrochemical-based point-of-care detection platforms that contribute to the diagnosis and monitoring of sepsis.

Identifiers

PMID37483649
PMCPMC10357885
OpenAlexW4365518071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.