Evidence map›Paper›PMID 37483610›Full record

ArticleFrontiers in immunology2023

β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression in

Minjing Zou, Suhad Al-Yahya, Monther Al-Alwan, Huda A BinEssa, Khalid S A Khabar, Falah Almohanna, Abdullah M Assiri, Abdulmohsen Altaweel, Amal Qattan, Brian F Meyer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Minjing ZouDepartment of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Suhad Al-YahyaDepartment of Molecular Biomedicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Monther Al-AlwanDepartment of Stem Cell & Tissue Re-engineering, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia and College of Medicine, Al-Faisal University, Riyadh, Saudi Arabia.
Huda A BinEssaDepartment of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Khalid S A KhabarDepartment of Molecular Biomedicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Falah AlmohannaDepartment of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Abdullah M AssiriDepartment of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Abdulmohsen AltaweelMawhiba, King Abdulaziz and His Companions Foundation for Giftedness and Creativity, Riyadh, Saudi Arabia.
Amal QattanDepartment of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Brian F MeyerCentre for Genomic Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ali S AlzahraniDepartment of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Yufei ShiDepartment of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
King Faisal Specialist Hospital & Research Centre · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: In the present study, we investigated the tumorigenicity of thyroid cancer cells derived from Results: Remarkably, the tumorigenic potential of BVE- Conclusions: Our results indicate that active β-catenin signaling inhibits NK cell-mediated immune responses against thyroid cancer cells. Targeting the β-catenin signaling pathway may have significant therapeutic benefits for

Indexed as

Carcinoma, PapillaryThyroid NeoplasmsAnimalsbeta CateninLigandsMembrane ProteinsMiceMice, NudeNK Cell Lectin-Like Receptor Subfamily KProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryUp-RegulationWnt Signaling Pathwaybeta CateninLigandsMembrane ProteinsNK Cell Lectin-Like Receptor Subfamily KProto-Oncogene Proteins B-rafRaet1c protein, mouseBRAFV600ECTNNB1NK cellsNKG2D ligandsthyroid cancerβ-catenin

Identifiers

PMID37483610
PMCPMC10358762
OpenAlexW4383371278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.