Evidence map›Paper›PMID 37483599›Full record

ArticleFrontiers in immunology2023

The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus.

Sandra Eltschkner, Samantha Mellinger, Soren Buus, Morten Nielsen, Kajsa M Paulsson, Karin Lindkvist-Petersson, Helena Westerdahl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Sandra EltschknerMolecular Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
Samantha MellingerMolecular Ecology and Evolution Lab, Department of Biology, Lund University, Lund, Sweden.
Soren BuusDepartment of Experimental Immunology, Institute of International Health, Immunology and Microbiology, Copenhagen, Denmark.
Morten NielsenImmunoinformatics and Machine Learning, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Kajsa M PaulssonAntigen Presentation, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Karin Lindkvist-PeterssonMedical Structural Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Helena WesterdahlMolecular Ecology and Evolution Lab, Department of Biology, Lund University, Lund, Sweden.
Lund University · SENetherlands Institute for Neuroscience · NLTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-distance migratory animals such as birds and bats have evolved to withstand selection imposed by pathogens across the globe, and pathogen richness is known to be particularly high in tropical regions. Immune genes, so-called Major Histocompatibility Complex (MHC) genes, are highly duplicated in songbirds compared to other vertebrates, and this high MHC diversity has been hypothesised to result in a unique adaptive immunity. To understand the rationale behind the evolution of the high MHC genetic diversity in songbirds, we determined the structural properties of an MHC class I protein, Acar3, from a long-distance migratory songbird, the great reed warbler

Indexed as

ChiropteraSongbirdsAnimalsAntigen PresentationHistocompatibility Antigens Class IHLA AntigensHumansPeptidesHistocompatibility Antigens Class IHLA AntigensPeptidesantigen presentationgreat reed warblerMajor Histocompatibility ComplexMHC class IPasseriformesX-ray structure

Identifiers

PMID37483599
PMCPMC10360169
OpenAlexW4383555457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.