Evidence map›Paper›PMID 37483530›Full record

ArticleBrain communications2023

Longitudinal associations between β-amyloid and cortical thickness in mild cognitive impairment.

Elijah Mak, Liwen Zhang, Chin Hong Tan, Anthonin Reilhac, Hee Youn Shim, Marcus Ong Qin Wen, Zi Xuen Wong, Eddie Jun Yi Chong, Xin Xu, Mary Stephenson and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Multimodal neuroimaging approach for cognitive impairment in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. White matterAlzheimer's research & therapy · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Friends and Foes in Alzheimer's Disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Elijah MakDepartment of Psychiatry, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom.ORCID https://orcid.org/0000-0002-6437-8024
Liwen ZhangMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Chin Hong TanDivision of Psychology, Nanyang Technological University, Singapore, 637331, Singapore.
Anthonin ReilhacClinical Imaging Research Centre, the Agency for Science, Technology and Research, and National University of Singapore, Singapore, 117599, Singapore.
Hee Youn ShimMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Marcus Ong Qin WenCentre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Zi Xuen WongMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Eddie Jun Yi ChongMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Xin XuMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Mary StephensonCentre for Translational MR Research (TMR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore.
Narayanaswamy VenketasubramanianRaffles Neuroscience Centre, Raffles Hospital, Singapore, 188770, Singapore.
Juan Helen ZhouCentre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
John T O'BrienDepartment of Psychiatry, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom.ORCID https://orcid.org/0000-0002-0837-5080
Christopher Li-Hsian ChenMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
National University of Singapore · SGUniversity of Cambridge · GBAgency for Science, Technology and Research · SGNanyang Technological University · SGRaffles Institution · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How beta-amyloid accumulation influences brain atrophy in Alzheimer's disease remains contentious with conflicting findings. We aimed to elucidate the correlations of regional longitudinal atrophy with cross-sectional regional and global amyloid in individuals with mild cognitive impairment and no cognitive impairment. We hypothesized that greater cortical thinning over time correlated with greater amyloid deposition, particularly within Alzheimer's disease characteristic regions in mild cognitive impairment, and weaker or no correlations in those with no cognitive impairment. 45 patients with mild cognitive impairment and 12 controls underwent a cross-sectional [

Indexed as

[11C]-PiB PETcortical thicknesslongitudinal cortical thinningmild cognitive impairmentregional β-amyloid

Identifiers

PMID37483530
PMCPMC10358322
OpenAlexW4383053865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.