ArticleFrontiers in neurology2023
Altered functional connectivity of the thalamus in patients with insomnia disorder after transcutaneous auricular vagus nerve stimulation therapy.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Default mode network and visual network responsiveness to transcutaneous auricular vagus nerve stimulation predict its variable efficacy in primary insomnia disorder.Frontiers in neurology · 2025Trial
- Acupuncture modulates emotional network resting-state functional connectivity in patients with insomnia disorder: a randomized controlled trial and fMRI study.BMC complementary medicine and therapies · 2024Trial
- Article
- Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Vagus Nerve Stimulation for Sleep Disorders: Emerging Evidence and Future Directions.Nature and science of sleep · 2026Review
- Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol.Frontiers in psychiatry · 2026Article
- Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
- Transcutaneous auricular vagus nerve stimulation inhibits food intake and body weight gain through the orexin dependent pathway in high fat diet mice.Scientific reports · 2025Article
- Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.European archives of psychiatry and clinical neuroscience · 2025Article
- Transcutaneous auricular vagus nerve stimulation improves cortical functional topological properties and intracortical facilitation in patients with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Insomnia Disorder: A Narrative Review of Effectiveness, Mechanisms and Recommendations for Clinical Practice.Nature and science of sleep · 2025Review
- Auricular Plaster Therapy for Preoperative Anxiety in Major Surgery: A Prospective Matched-Cohort Study of Total Knee Arthroplasty and Pancreaticoduodenectomy Patients.Journal of pain research · 2025Article
- Article
- The central regulatory effects of acupuncture in treating primary insomnia: a review.Frontiers in neurology · 2024Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of insomnia is related to the dysfunction of the thalamus. Transcutaneous auricular vagus nerve stimulation (taVNS) has proved to be effective in treating insomnia. However, whether taVNS alleviates insomnia through modulating thalamus-related functional connectivity remains unclear. To elucidate the instant modulating effects of taVNS on the resting state functional connectivity (RSFC) of the thalamus, 20 patients with insomnia disorder were recruited to receive taVNS treatment and their resting state functional magnetic resonance imaging (fMRI) data were collected immediately before and after stimulation. The fMRI data were compared with 20 age- and gender-matched healthy subjects who received no stimulation and had RSFC fMRI data collected once. RSFC analyses of the thalamus were performed in both groups. In addition to assessing the group differences between ID patients and healthy controls regarding the RSFC of the thalamus, we examined the taVNS-induced changes of RSFC of the thalamus in ID patients. Before taVNS treatment, the ID patients showed increased RSFC of the thalamus with the right insula and inferior frontal gyrus than healthy controls. After taVNS treatment, the RSFC between the thalamus and the right angular gyrus, left anterior cingulate gyrus, and precuneus were significantly decreased in patients. This study provides insights into the instant brain effects involving the thalamus-related functional connectivity of taVNS performed on insomnia disorder patients.
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