Evidence map›Paper›PMID 37483315›Full record

ArticleInternational journal of nanomedicine2023

Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation.

Ming-Jun Tsai, Cheng-Yu Lin, Jiří Trousil, Calvin T Sung, Mei-Hua Lee, Jia-You Fang, Shih-Chun Yang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Ming-Jun TsaiSchool of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-0338-3639
Cheng-Yu LinPharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Jiří TrousilInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
Calvin T SungDepartment of Dermatology, University of California, Irvine, CA, USA.
Mei-Hua LeePharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Jia-You FangPharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.ORCID 0000-0003-2114-7709
Shih-Chun YangDepartment of Microbiology, Soochow University, Taipei, Taiwan.
Chang Gung University · TWChang Gung University of Science and Technology · TWCzech Academy of Sciences, Institute of Macromolecular Chemistry · CZKaohsiung Medical University · TWSoochow University · TWUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Simultaneous anti- Materials and Methods: This study examined in vitro planktonic and biofilm Results: We acquired multifunctional liposomes with a size of 71 nm and zeta potential of 31 mV. The antimicrobial activity of SME was enhanced after liposomal encapsulation according to the reduction of minimum bactericidal concentration (MBC) by 6-fold. The multifunctional liposomes exhibited a synergistically inhibitory effect on biofilm Conclusion: The cationic liposomes containing dual PK and RA represented a potential treatment to arrest bacterial infection and associated inflammation in acne.

Indexed as

Acne VulgarisLiposomesAnimalsAnti-Bacterial AgentsBiofilmsCell ProliferationEndopeptidase KKeratinocytesMiceTretinoinAnti-Bacterial AgentsEndopeptidase KLiposomesTretinoinacneCutibacterium acnesliposomeproteinase Kretinoic acidskin delivery

Identifiers

PMID37483315
PMCPMC10361279
OpenAlexW4384563761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.