Evidence map›Paper›PMID 37483203›Full record

ArticleACS omega2023

Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid Dispersion Carriers for Enhanced Aqueous Solubility,

Darshan R Telange, Neha M Bhaktani, Atul T Hemke, Anil M Pethe, Surendra S Agrawal, Nilesh R Rarokar, Shirish P Jain

Abstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Darshan R TelangeDatta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442002, Maharashtra, India.ORCID https://orcid.org/0000-0003-3016-8237
Neha M BhaktaniSmt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur 441002, Maharashtra, India.
Atul T HemkeSmt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur 441002, Maharashtra, India.
Anil M PetheDatta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442002, Maharashtra, India.
Surendra S AgrawalDatta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442002, Maharashtra, India.
Nilesh R RarokarRashtrasant Tukadoji Maharaj Nagpur University, Department of Pharmaceutical Sciences, Mahatma Jyotiba Fuley Shaik Shanik Parisar, University Campus, Amravati Road, Nagpur 440033, Maharashtra, India.ORCID https://orcid.org/0000-0003-3401-7997
Shirish P JainRajarshi Shahu College of Pharmacy, Malvihir, Buldana 443001, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atorvastatin (ATV), a lipid-lowering agent, has low oral bioavailability due to its poor water solubility, permeability, and low dissolution rate. Therefore, pentaerythritol-EudragitRS100 co-processed excipients (PECE) were synthesized, and their feasibility as solid dispersion carriers (ATV-PECE-SD) for improving the solubility, permeability, and dissolution rate of ATV was explored. Solid dispersions were assessed in terms of particle size and zeta potential, and solubility,

Identifiers

PMID37483203
PMCPMC10357539

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.