Evidence map›Paper›PMID 37483063›Full record

ArticleJournal of diabetes investigation2023

Polar vasculosis is associated with better kidney outcome in type 2 diabetes with biopsy-proven diabetic kidney disease: A multicenter cohort study.

Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Masayuki Yamanouchi, Junichi Hoshino, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Yukio Yuzawa and 17 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 17 institutions in 1 country.

Miho ShimizuDepartment of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0000-0002-7737-935X
Kengo FuruichiDepartment of Nephrology, Kanazawa Medical University, Uchinada, Japan.
Tadashi ToyamaDepartment of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Masayuki YamanouchiNephrology Center, Toranomon Hospital, Tokyo, Japan.
Junichi HoshinoNephrology Center, Toranomon Hospital, Tokyo, Japan.
Shinji KitajimaDepartment of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Akinori HaraDepartment of Hygiene and Public Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yasunori IwataDepartment of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Norihiko SakaiDepartment of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yukio YuzawaFujita Health University, Toyoake, Japan.
Hiroshi KitamuraDepartment of Pathology, National Hospital Organization Chiba-Higashi National Hospital, Chiba, Japan.
Hiroshi SatoJR Sendai Hospital, Sendai, Japan.
Yugo ShibagakiDivision of Nephrology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan.
Yoshiki SuzukiDivision of Clinical Nephrology and Rheumatology, Niigata University Medical and Dental Hospital, Niigata, Japan.
Noriko UesugiDepartment of Pathology, Fukuoka University, Fukuoka, Japan.
Yoshihiko UedaDepartment of Pathology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.
Kentaro KohaguraDialysis Unit, University of the Ryukyus Hospital, Nakagami-gun, Japan.
Kenichi SamejimaDepartment of Nephrology, Nara Medical University, Kashihara, Japan.
Kazuhiko TsuruyaDepartment of Nephrology, Nara Medical University, Kashihara, Japan.
Shinichi NishiDivision of Nephrology and Kidney Center, Kobe University Graduate School of Medicine School of Medicine, Kobe, Japan.
Tomoya NishinoDepartment of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.
Hirofumi MakinoOkayama University, Okayama, Japan.
Seiichi MatsuoNagoya University, Nagoya, Japan.
Yoshifumi UbaraNephrology Center, Toranomon Hospital, Tokyo, Japan.
Hitoshi YokoyamaDepartment of Nephrology, Kanazawa Medical University, Uchinada, Japan.
Takashi WadaDepartment of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Research Group of Diabetic Nephropathy, the Ministry of Health, Labour and Welfare, and the Japan Agency for Medical Research and Development
Kanazawa University · JPKanazawa Medical University · JPNara Medical University · JPToranomon Hospital · JPDokkyo Medical University Saitama Medical Center · JPFujita Health University · JPFukuoka University · JPKobe University · JPNagasaki University Hospital · JPNagoya University · JPNational Hospital Organization · JPNiigata University Medical and Dental Hospital · JPOkayama University · JPSendai Shakai Hoken Hospital · JPSt. Marianna University School of Medicine · JPTokyo Women's Medical University · JPUniversity of the Ryukyus University Hospital · JP

Funding

Grant-in-Aid for Diabetic Nephropathy and Nephrosclerosis Research from the Ministry of Health, Labour and Welfare of JapanGrant-in-Aid for Practical Research Project for Renal Diseases, from the Japan Agency for Medical Research and Development JP17ek0310003
6 · The paper itself

Abstract

AIMS/

introductionThis multicenter cohort study retrospectively assessed the association between polar vasculosis and the progression of diabetic kidney disease (DKD) in type 2 diabetes. MATERIALS AND

methodsWe enrolled 811 patients with type 2 diabetes, biopsy-proven DKD, and proteinuria (≥0.15 g/g creatinine [g/day]). The association between polar vasculosis and other kidney lesions was explored. The outcome was DKD progression defined as a composite of renal replacement therapy initiation or 50% decline in estimated glomerular filtration rate (eGFR) from baseline.

resultsOf the 811 cases, 677 (83.5%) had polar vasculosis. In multivariate logistic regression analysis, subendothelial widening of the glomerular basement membrane, glomerulomegaly, glomerular class in the Renal Pathology Society classification ≥IIb, vascular lesions, age, eGFR, and hemoglobin A1c were positively associated with polar vasculosis, whereas interstitial fibrosis and tubular atrophy (IFTA) was negatively associated with polar vasculosis. During a median follow-up of 5.2 years, progression of DKD occurred in 322 of 677 (7.4 events/100 person-years) and 79 of 134 (11.4 events/100 person-years) cases with and without polar vasculosis, respectively. Kaplan-Meier analysis showed that polar vasculosis was associated with lower cumulative incidences of DKD progression. Multivariate Cox regression analyses showed that polar vasculosis was associated with a lower risk of DKD progression, regardless of eGFR or proteinuria subgroups. These associations between polar vasculosis and better kidney outcome were unchanged considering all-cause mortality before DKD progression as a competing event.

conclusionsThis study showed that polar vasculosis of DKD was associated with less advanced IFTA and a better kidney outcome in type 2 diabetes with proteinuria.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesBiopsyCohort StudiesDisease ProgressionHumansKidneyProteinuriaRetrospective StudiesDiabetic kidney diseaseKidney outcomePolar vasculosis

Identifiers

PMID37483063
PMCPMC10583646
OpenAlexW4385146073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.