Trial reportEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023
Three-year outcomes of A Randomized Multicentre Trial Comparing Revascularization and Optimal Medical Therapy for Chronic Total Coronary Occlusions (EuroCTO).
Trial report in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Multicentre Trial to Evaluate the Utilization of Revascularization or Optimal Medical Therapy for the Treatment of Chronic Total Coronary Occlusions
The Value of FAPI Imaging for the Prediction of Adverse Cardiovascular Events in Chronic Total Occlusion of Coronary Artery Disease (FACT-2 Trial)
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review and meta-analysis of the use of drug-coated balloon angioplasty for treatment of both de novo and in-stent coronary chronic total occlusions.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Pooled it
- Ten-Year Outcome of Recanalization or Medical Therapy for Concomitant Chronic Total Occlusion After Myocardial Infarction.Journal of the American Heart Association · 2024Trial
- Left Ventricular Mechanics in Multivessel Coronary Artery Disease with Versus Without Chronic Total Occlusion.Journal of cardiovascular development and disease · 2026Article
- Electrocardiographic Changes After Percutaneous Coronary Intervention for Chronic Total Occlusion.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Association Between Optimal Revascularization for Chronic Total Occlusion and Long-Term Outcomes in Patients With Heart Failure With or Without Type 2 Diabetes.Journal of the American Heart Association · 2026Article
- Complex CTO Revascularization in Patients with Ischemic Heart Failure and Reduced Ejection Fraction: An Illustrative Case Series.Journal of clinical medicine · 2026Article
- Rentrop collateral grade predicts myocardial viability in chronic total occlusion on cardiac magnetic resonance.Open heart · 2026Article
- Percutaneous coronary intervention or conservative therapy for chronic total coronary occlusions (CTOs)? Evidence from the ISCHEMIA trial.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Angiography-derived assessment of coronary microcirculatory resistance in patients with chronic total occlusion.Heart and vessels · 2026Article
- The Prognostic Value of Left Atrial Size and Strain Assessed by Cardiac Magnetic Resonance in the Coronary Chronic Total Occlusion.Journal of cardiovascular development and disease · 2026Article
- Coronary CT Angiography for PCI Planning and Guidance: A Comprehensive Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- XGBoost based machine learning prediction model for major adverse cardiovascular events after PCI in STEMI patients.Scientific reports · 2026Article
- Non-invasive multiparametric evaluation of patients with chronic total occlusions compared with single-photon emission computed tomography results.Cardiology journal · 2026Article
- Impact of coronary calcium patterns on procedural outcomes in CTO-PCI: a computed tomography-based multicenter study.Cardiovascular intervention and therapeutics · 2026Article
- Coronary Chronic Total Occlusions Affect Long-Term Prognosis in Heart Failure With Mildly Reduced Ejection Fraction.Journal of the American Heart Association · 2025Observational
- The Role of Myocardial Revascularization in Ischemic Heart Failure in the Era of Modern Optimal Medical Therapy.Medicina (Kaunas, Lithuania) · 2025Review
- The Role of Intravascular Imaging in Coronary Chronic Total Occlusion PCI: Enhancing Procedural Success Through Real-Time Visualization.Journal of personalized medicine · 2025Review
- Chronic Total Occlusions: Current Approaches, Evidence and Outcomes.Journal of clinical medicine · 2025Review
- Emerging Applications of Positron Emission Tomography in Coronary Artery Disease.Journal of personalized medicine · 2025Review
- Procedural success prediction in chronic total occlusion percutaneous coronary intervention (CTO-PCI)-the rise of the machines?Cardiovascular diagnosis and therapy · 2024Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 11 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPercutaneous coronary intervention (PCI) for chronic total coronary occlusions (CTO) improves clinical symptoms and quality of life. The longer-term safety of PCI compared to optimal medical therapy (OMT) remains uncertain.
aimsWe sought to evaluate the long-term safety of PCI for CTO in a randomised trial as compared to OMT.
methodsA total of 396 patients with a symptomatic CTO were enrolled into a randomised, multicentre clinical trial comparing PCI and OMT. Half of the patients had a single CTO; the others had multivessel disease. Non-CTO lesions were treated prior to randomisation (2:1 ratio). During follow-up, crossover from OMT to PCI occurred in 7.3% (1 year) and 17.5% (3 years) of patients.
resultsAt 3 years, the incidence of cardiovascular death or nonfatal myocardial infarction was not significantly different between the groups (OMT 3.7% vs PCI 6.2%; p=0.29). By per-protocol analysis, the difference remained non-significant (OMT 5.7% vs PCI 4.7%; p=0.67). Overall, major adverse cardiovascular events (MACE) were more frequent with OMT (OMT 21.2% vs PCI 11.2%), largely because of ischaemia-driven revascularisation. The rates of stroke or hospitalisation for bleeding were not different between the groups.
conclusionsAt 3 years there was no difference in the rate of cardiovascular death or myocardial infarction between PCI or OMT among patients with a remaining single coronary CTO. The MACE rate was higher in the OMT group due largely to ischaemia-driven revascularisation. CTO PCI appears to be a safe option for patients with a single remaining significant coronary CTO. CinicalTrials.gov: NCT01760083.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.