ArticleBiomechanics and modeling in mechanobiology2023
A homogenized constrained mixture model of cardiac growth and remodeling: analyzing mechanobiological stability and reversal.
Article in Biomechanics and modeling in mechanobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A modelling study of right ventricular growth with valvular regurgitation.Biomechanics and modeling in mechanobiology · 2026Article
- Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life.Biomechanics and modeling in mechanobiology · 2025Review
- Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- Synergistic biophysics and machine learning modeling to rapidly predict cardiac growth probability.Computers in biology and medicine · 2025Article
- Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling.Biomechanics and modeling in mechanobiology · 2024Article
- FSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.Computer methods in applied mechanics and engineering · 2024Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease.Annals of biomedical engineering · 2024Article
- The role of computational methods in cardiovascular medicine: a narrative review.Translational pediatrics · 2024Review
- A Fluid-Solid-Growth Solver for Cardiovascular Modeling.Computer methods in applied mechanics and engineering · 2023Article
- Beyond CFD: Emerging methodologies for predictive simulation in cardiovascular health and disease.Biophysics reviews · 2023Review
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Authors and funding
5 authors.
Funding
Abstract
Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function both globally and locally. Biomechanical, neurohormonal, and genetic stimuli drive these patterns through changes in myocyte dimension and fibrosis. We propose a novel microstructure-motivated model that predicts organ-scale G&R in the heart based on the homogenized constrained mixture theory. Previous models, based on the kinematic growth theory, reproduced consequences of G&R in bulk myocardial tissue by prescribing the direction and extent of growth but neglected underlying cellular mechanisms. In our model, the direction and extent of G&R emerge naturally from intra- and extracellular turnover processes in myocardial tissue constituents and their preferred homeostatic stretch state. We additionally propose a method to obtain a mechanobiologically equilibrated reference configuration. We test our model on an idealized 3D left ventricular geometry and demonstrate that our model aims to maintain tensional homeostasis in hypertension conditions. In a stability map, we identify regions of stable and unstable G&R from an identical parameter set with varying systolic pressures and growth factors. Furthermore, we show the extent of G&R reversal after returning the systolic pressure to baseline following stage 1 and 2 hypertension. A realistic model of organ-scale cardiac G&R has the potential to identify patients at risk of heart failure, enable personalized cardiac therapies, and facilitate the optimal design of medical devices.
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