ArticleScientific reports2023
Disease burden of congenital Zika virus syndrome in Brazil and its association with socioeconomic data.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond the Mosquito: Social Determinants of Health and Global Strategies for Aedes-Borne Disease Control.Tropical medicine & international health : TM & IH · 2026Pooled it
- Maternal High Fat Diet and Acute Viral Mimic Exposure Impact Placental Inflammation, Lipid Peroxidation and Cellular Proliferation-to-Death Ratio Across Mouse Pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Exploratory strain-associated patterns of antiviral transcriptional responses to Zika virus exposure in developing human neural tissue.Genomics & informatics · 2026Article
- Neurological complications of Zika virus and their impact on quality of life: a narrative review.Tropical medicine and health · 2026Review
- Temporal trends and maternal factors associated with congenital anomalies among live births in São Paulo, Brazil: a population-based study, 2015-2023.BMC pregnancy and childbirth · 2026Article
- Health and economic burdens of emerging infectious diseases in the USA, US territories and globally.BMJ global health · 2026Article
- Maternal adaptation to caring for a child with congenital Zika virus syndrome.Revista brasileira de enfermagem · 2026Article
- Understanding the social determinants of Aedes-borne diseases in Iran: A qualitative exploration of challenges and policy solutions.PLoS neglected tropical diseases · 2025Article
- Epidemiological surveillance in congenital anomalies and rare diseases in Brazil: present situation and future challenges.Journal of community genetics · 2025Review
- A decade later, what have we learned from the Zika epidemic in children with intrauterine exposure?Lancet (London, England) · 2025Review
- Future threats: Animal orthoflaviviruses that currently infect fewer than 100 people per year.Cell reports · 2025Review
- Flavivirus infections and diagnostic challenges for dengue, West Nile and Zika Viruses.Npj viruses · 2025Review
- Mothers and mosquitoes: climate change contributes to the spread of vector-borne pathogens posing a substantial threat to pregnant women.Seminars in immunopathology · 2025Review
- (Re)Emerging Arboviruses of Public Health Significance in the Brazilian Amazon.Microorganisms · 2025Review
- Early and Long-Term Adverse Outcomes of In Utero Zika Exposure.Pediatrics · 2025Article
- Estimating per-infection cost and burden for dengue and Zika as a function of antibody-dependent enhancement.PLoS neglected tropical diseases · 2025Article
- Spatial analysis of risk areas of congenital anomalies in Brazil, 2012-2021.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- The lingering crisis: gaps in long-term care for children with congenital Zika syndrome and their families in Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface.Memorias do Instituto Oswaldo Cruz · 2025Review
- Serious Concern of Congenital Zika Syndrome (CZS) in India: A Narrative Review.Journal of pregnancy · 2024Review
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6 authors.
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Abstract
Zika virus (ZIKV) infection became a global public health concern, causing an epidemic in Latin America from 2015 to 2016, when a sudden increase in cases of microcephaly and other congenital anomalies was observed. In 2016, the Centers for Disease Control and Prevention and the World Health Organization defined congenital Zika-associated syndrome (CZS) as a set of congenital anomalies seen in children born to mothers with a history of gestational Zika fever, who have microcephaly as the most prevalent clinical sign. In order to describe the magnitude of CZS in Brazil, this study estimated the burden of disease due to CZS in Brazil using the disability-adjusted life years (DALY) indicator and other frequency measures, such as incidence and mortality rate, during the years 2015-2020. The association of these indicators with socioeconomic variables was also evaluated using Spearman's correlation coefficient. Choropleth maps were used to evaluate the spatial distribution of the indicators evaluated and the spatial autocorrelation was verified by the Bivariate Moran Local Index. From 2015 to 2020, 3,591 cases of CZS were confirmed in Brazil, with an incidence of 44.03 cases per 1000 live births, and a specific mortality of 12.35 deaths per 1000 live births. A global loss of 30,027.44 DALYs was estimated from 2015 to 2020. The Northeast region had the highest values for all health indicators assessed. Spatial correlation and autocorrelation analyses showed significant associations between health and socioeconomic indicators, such as per capita income, Gini index, illiteracy rate and basic sanitation. The study allowed us to have access to all reported cases of CZS, showing us the possible situation of the disease in Brazil; therefore, we believe that our results can help in the understanding of future studies.
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