ArticleDiabetes research and clinical practice2023
One-hour glucose is an earlier marker of dysglycemia than two-hour glucose.
Article in Diabetes research and clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Clinical utility of 1-h post-load glucose in accelerating diagnosis of type 2 diabetes: a prospective cohort study.Acta diabetologica · 2026Article
- Children born SGA receiving growth hormone have similarly impaired glucose-insulin metabolism as children with obesity.The Journal of clinical endocrinology and metabolism · 2026Article
- Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.American journal of physiology. Endocrinology and metabolism · 2026Article
- Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbADiabetologia · 2026Article
- Redefining β-Cell Function in Type 2 Diabetes Mellitus: From Comprehensive Assessment to Precision Medicine.Diabetes & metabolism journal · 2026Review
- Diagnostic performance of 1-hour plasma glucose and glucose curve shape during oral glucose tolerance test: a cross-sectional study in a Brazilian cohort.Diabetology & metabolic syndrome · 2025Article
- Clinical characteristics of Japanese Americans with normal glucose tolerance with 1-h hyperglycemia: A cross-sectional study.Journal of diabetes investigation · 2025Article
- Prediabetes.Nature reviews. Disease primers · 2025Review
- Brazilian guideline for screening and diagnosis of type 2 diabetes: a position statement from the Brazilian Diabetes Society.Diabetology & metabolic syndrome · 2025Article
- High one-hour plasma glucose is an intermediate risk state and an early predictor of type 2 diabetes in a longitudinal Korean cohort.Diabetes research and clinical practice · 2025Article
- Performance of the 1 h oral glucose tolerance test in predicting type 2 diabetes and association with impaired β-cell function in Asians: a national prospective cohort study.The Lancet regional health. Western Pacific · 2025Article
- One-Hour Postload Glucose Is a More Sensitive Marker of Impaired β-Cell Function Than Two-Hour Postload Glucose.Diabetes · 2025Article
- Staging schema for early diagnosis of prediabetes.The lancet. Diabetes & endocrinology · 2024Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
aimsThe timing of increase in 1-hour PG and its utility as an earlier predictor of both prediabetes (PreDM) and type 2 diabetes (T2D) compared to 2-hour PG (2 h-PG) are unknown. To evaluate the timing of crossing of the 1 h-PG ≥ 155 mg/dl (8.6 mmol/L) for PreDM and 209 mg/dl (11.6 mmol/L) for T2D and respective current 2 h-PG thresholds of 140 mg/dl (7.8 mmol/L) and 200 mg/dl (11.1 mmol/L).
methodsSecondary analysis of 201 Southwest Native Americans who were followed longitudinally for 6-10 years and had at least 3 OGTTs.
resultsWe identified a subset of 43 individuals who first developed PreDM by both 1 h-PG and 2 h-PG criteria during the study. For most (32/43,74%), 1 h-PG ≥ 155 mg/dl was observed before 2 h-PG reached 140 mg/dl (median [IQR]: 1.7 [-0.25, 4.59] y; mean ± SEM: 5.3 ± 1.9 y). We also identified a subset of 33 individuals who first developed T2D during the study. For most (25/33, 75%), 1 h-PG reached 209 mg/dl earlier (median 1.0 [-0.56, 2.02] y; mean ± SEM: 1.6 ± 0.8 y) than 2 h-PG reached 200 mg/dl, diagnostic of T2D.
conclusions1 h-PG ≥ 155 mg/dl is an earlier marker of elevated risk for PreDM and T2D than 2 h-PG ≥ 140 mg/dl.
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