Evidence map›Paper›PMID 37481766›Full record

ArticleCellular and molecular life sciences : CMLS2023

GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo.

E P Moreno-Jiménez, M Flor-García, A Hernández-Vivanco, J Terreros-Roncal, C B Rodríguez-Moreno, N Toni, P Méndez, María Llorens-Martín

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

E P Moreno-JiménezDepartment of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM) (Campus de Cantoblanco), c/Nicolás Cabrera 1, 28049, Madrid, Spain.
M Flor-García *Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM) (Campus de Cantoblanco), c/Nicolás Cabrera 1, 28049, Madrid, Spain.
A Hernández-Vivanco *Cajal Institute, CSIC, Madrid, Spain.
J Terreros-RoncalDepartment of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM) (Campus de Cantoblanco), c/Nicolás Cabrera 1, 28049, Madrid, Spain.
C B Rodríguez-MorenoDepartment of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM) (Campus de Cantoblanco), c/Nicolás Cabrera 1, 28049, Madrid, Spain.
N ToniDepartment of Psychiatry, Center for Psychiatric Neurosciences, , Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
P MéndezCajal Institute, CSIC, Madrid, Spain.
María Llorens-MartínDepartment of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM) (Campus de Cantoblanco), c/Nicolás Cabrera 1, 28049, Madrid, Spain. m.llorens@csic.es.ORCID http://orcid.org/0000-0001-9129-5198
Biomedical Research Networking Center on Neurodegenerative Diseases · ESInstituto Cajal · ESUniversity of Lausanne · CH

Funding

Alzheimer's Association 2015-NIRG-340709Alzheimer's Association AARG-17-528125Alzheimer's Association AARG-17-528125-RAPIDEuropean Research Council 101001916
6 · The paper itself

Abstract

Adult hippocampal neurogenesis enhances brain plasticity and contributes to the cognitive reserve during aging. Adult hippocampal neurogenesis is impaired in neurological disorders, yet the molecular mechanisms regulating the maturation and synaptic integration of new neurons have not been fully elucidated. GABA is a master regulator of adult and developmental neurogenesis. Here we engineered a novel retrovirus encoding the fusion protein Gephyrin:GFP to longitudinally study the formation and maturation of inhibitory synapses during adult hippocampal neurogenesis in vivo. Our data reveal the early assembly of inhibitory postsynaptic densities at 1 week of cell age. Glycogen synthase kinase 3 Beta (GSK-3β) emerges as a key regulator of inhibitory synapse formation and maturation during adult hippocampal neurogenesis. GSK-3β-overexpressing newborn neurons show an increased number and altered size of Gephyrin

Indexed as

HippocampusNeuronsAdultBrainGlycogen Synthase Kinase 3 betaHumansInfant, NewbornNeurogenesisGlycogen Synthase Kinase 3 betaGSK3B protein, humanAdult hippocampal neurogenesisAlzheimer´s diseaseBehaviorElectrophysiologyGephyrinGSK-3βRetrovirus

Identifiers

PMID37481766
PMCPMC10363517
OpenAlexW4385173593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.