ArticleClinical oral investigations2023
Regenerative endodontic treatment using autologous blood from alveolar bone for mature permanent premolar with apical periodontitis: a case report.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Evaluation of the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic molar teeth with open apex on postoperative pain- randomized clinical trial.Clinical oral investigations · 2025Trial
- Regenerative endodontic treatment for premolars with apical root segment separation and extensive periapical lesions secondary to severe inflammatory root resorption: A report of two cases.Experimental and therapeutic medicine · 2026Article
- Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth.Bioinformation · 2026Article
- An observational study of alveolar-derived autologous blood clot used in regenerative endodontic treatment for immature permanent teeth with pulp necrosis.Clinical oral investigations · 2025Observational
- Alveolar-derived autologous blood clot as a scaffold for regenerative endodontic treatment: An observational study.Bioinformation · 2025Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
objectiveThe formation of blood clot, achieved through periapical bleeding or the use of peripheral venous blood, platelet-rich plasma (PRP) or platelet-rich fibrin (PRF), has been widely utilized in regenerative endodontic procedures (REPs). Except for inducing periapical bleeding, the scaffolds obtained from PRP, PRF, and venous blood are not derived from oral and maxillofacial tissues. In this case report, autologous blood clots from alveolar bone were described, which involved puncturing the maxillary terminal alveolar bone. The purpose of this case report was to assess the efficacy of the alveolar-derived blood clot in regenerative endodontic procedures in a mature permanent premolar.
methodsA mature premolar had a fractured central cusp, one of the developmental aberrations of tooth, without a proper treatment, resulting in chronic periapical lesion. To address this condition, REPs were employed, utilizing blood obtained through aspiration from the maxillary terminal alveolar bone aspiration.
resultFollow-up examinations of tooth #29 revealed the absence of clinical symptoms, a progressive resolution of a periapical lesion area and thickening of the root canal walls.
conclusionThis case demonstrated that blood clot obtained through paracentesis of the maxillary terminal alveolar bone could be successfully applied in REPs and has potential to manage periapical lesions. However, further and more clinical trials are required to verify the feasibility of the alveolar-derived blood clot in REPs and compare the outcome of alveolar-derived blood clot with currently used biological scaffolds. CLINICAL RELEVANCE: In comparison to PRP or PRF from peripheral venous blood, blood clots obtained via paracentesis of the maxillary terminal alveolar bone could be administrated by dentists, eliminating the need for reliance on professional nurses. The use of blood clots from alveolar bone could simplify the REPs in cases where periapical blood was insufficient to brim the root canals.
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